Interleukin-18 production and pulmonary function in COPID
Interleukin-18 production and pulmonary function in COPID
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DOI：
10.1183/09031936.00019207
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发表时间：
2008-02-01
影响因子：
24.3
通讯作者：
Aizawa, H.
中科院分区：
文献类型：
--
作者：
Imaoka, H.;Hoshino, T.;Aizawa, H.
Interleukin (IL)-18 production and pulmonary function were evaluated in patients with chronic obstructive pulmonary disease (COPD) in order to determine the role of IL-18 in COPD.Immunohistochemical techniques were used to examine IL-18 production in the lungs of patients with very severe COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage IV, n=16), smokers (n=27) and nonsmokers (n=23). Serum cytokine levels and pulmonary function were analysed in patients with GOLD stage I-IV COPD (n=62), smokers (n=34) and nonsmokers (n=47).Persistent and severe small airway inflammation was observed in the lungs of ex-smokers with very severe COPD. IL-18 proteins were strongly expressed in alveolar macrophages, CD8+ T-cells, and both the bronchiolar and alveolar epithelia in the lungs of COPD patients. Serum levels of IL-18 in COPD patients and smokers were significantly higher than those in nonsmokers. Moreover, serum levels of IL-18 in patients with GOLD stage III and IV COPD were significantly higher than in smokers and nonsmokers. There was a significant negative correlation between serum IL-18 level and the predicted forced expiratory volume in one second in patients with COPD. In contrast, serum levels of IL-4, IL-13 and interferon-gamma were not significantly increased in any of the three groups.In conclusion, overproduction of interleukin-18 in the lungs may be involved in the pathogenesis of chronic obstructive pulmonary disease.
