A reductionist's systems biology: opinion.
A reductionist's systems biology: opinion.
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DOI：
10.1016/j.ceb.2004.12.012
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发表时间：
2005-02
影响因子：
7.5
通讯作者：
P. Sorger
中科院分区：
文献类型：
--
作者：
P. Sorger
为了解决理解相互作用的生物分子的大型网络所固有的复杂性，系统生物学强调控制论和系统理论方法。由此产生的对独立于物理表现的组织的关注有可能抛弃从分子研究中学到的所有知识，并忽视了这样一个事实：生物学家更多地是由于对机制和结构的共同兴趣而不是其他任何东西而聚集在一起。反应工程领域提出了一种简化系统生物学的方法，这种方法很容易适用于现有的分子范式，但仍然可以通过使用多尺度建模将其整合到广阔的生理学视角中。
To tackle the complexity inherent in understanding large networks of interacting biomolecules, systems biology emphasizes cybernetic and systems theoretical approaches. The resulting focus on organization independent of physical manifestation threatens to throw away all that has been learned from molecular studies and ignores the reality that biologists are drawn together more by a shared interest in mechanism and structure than anything else. The field of reaction engineering suggests a reductionist approach to systems biology that fits easily within existing molecular paradigms but that can nonetheless be integrated into expansive physiological perspectives through the use of multi-scale modeling.