A PROSPECTIVE-STUDY OF DEHYDROEPIANDROSTERONE SULFATE, MORTALITY, AND CARDIOVASCULAR-DISEASE
A PROSPECTIVE-STUDY OF DEHYDROEPIANDROSTERONE SULFATE, MORTALITY, AND CARDIOVASCULAR-DISEASE
复制标题
DOI：
10.1056/nejm198612113152405
复制
发表时间：
1986-12-11
影响因子：
158.5
通讯作者：
YEN, SSC
中科院分区：
文献类型：
--
作者：
BARRETTCONNOR, E;KHAW, KT;YEN, SSC
脱氢表雄酮（DHEA）及其硫酸酯、脱氢表雄酮硫酸酯（DHEA）及其硫酸酯、脱氢表雄酮硫酸酯（DHEAS）是人体肾上腺的主要分泌产物，被认为可能是预期寿命和衰老的鉴别因子。我们在研究开始时对242名年龄在50 - 79岁的男性进行了基于人群的队列研究，研究了基线循环DHEAS水平与随后12年内任何原因、心血管疾病和缺血性心脏病死亡率的关系。平均DHEAS水平随着年龄的增长而下降，并且在有心脏病史的男性中也显著低于没有心脏病史的男性。在基线时没有心脏病史的男性中，与DHEAS水平低于140微克/分升相关的年龄调整后的任何原因死亡的相对风险为1.5（P不显著），3.3。心血管疾病死亡率为3.2（P < 0.05），缺血性心脏病死亡率为3.2（P < 0.02）。在多变量分析中，DHEAS水平每分升增加100 μ g与任何原因导致的死亡率降低36（P < 0.05），心血管疾病死亡率降低48%（P < 0.05），在校正年龄、收缩压、血清胆固醇水平、肥胖、空腹血糖水平、吸烟状况后，和个人心脏病史我们的结论受到DHEAS水平单一测定的限制，但数据表明，DHEAS浓度与50岁以上男性的任何原因死亡和心血管疾病死亡独立且呈负相关。
It has been postulated that dehydroepiandrosterone (DHEA) and its sulfate ester, dehydroepiandrosterone sulfate (DHEA) and its sulfate ester, dehydroepiandrosterone sulfate (DHEAS), the major secretory products of the human adrenal gland, may be discriminators of life expectancy and aging. We examined the relation of base-line circulating DHEAS levels to subsequent 12-year mortality from any cause, from cardiovasular disease, and from ischemic heart disease in a population-based cohort of 242 men aged 50 to 79 years at the start of the study. Mean DHEAS levels decreased with age and were also significantly lower in men with a history of heart disease than in those without such a history. In men with no history of heart disease at base line, the age-adjusted relative risk associated with a DHEAS level below 140 .mu.g per deciliter was 1.5 (P not significant) for death from any causes, 3.3. (P < 0.05) for death from cardiovascular disease, and 3.2 (P < 0.02) for death from ischemic heart disease. In multivariate analyses, an increase in DHEAS level of 100 .mu.g per deciliter was associated with a 36 percent reduction in mortality from any causes (P < 0.05) and a 48 percent reduction in mortality from cardiovascular disease (P < 0.05), after adjustment for age, systolic blood pressure, serum cholesterol level, obesity, fasting plasma glucose level, cigarette smoking status, and personal history of heart disease. Our conclusions are limited by the single determination of DHEAS levels, but the data suggest that the DHEAS concentration is indepnedently and inversely related to death from any cause and death from cardiovascular disease in men over age 50.