Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis.

Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis.
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DOI:
10.1038/nchembio.159
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发表时间:
2009-06
影响因子:
14.8
通讯作者:
Clardy, Jon
Clardy, Jon
中科院分区:
生物学1区
文献类型:
--
作者:
Oh, Dong-Chan;Poulsen, Michael;Currie, Cameron R.;Clardy, Jon

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真菌生长的蚂蚁与它们为食物而培育的真菌和放线菌(假心菌属)相互依存,放线菌产生选择性抗生素,以保护真菌免受特定真菌寄生虫的侵害。在第一个在分子水平上分析的系统中,与蚂蚁Apterostigma dentigerum相关的细菌产生牙霉霉素,一种氨基酸高度修饰的环状沉积肽,选择性地抑制寄生真菌(Escovopsis sp.)。
Fungus-growing ants engage in mutualistic associations with both the fungus they cultivate for food and actinobacteria (Pseudonocardia spp.) that produce selective antibiotics to defend that fungus from specialized fungal parasites. In the first system to be analyzed at the molecular level, the bacterium associated with the ant Apterostigma dentigerum produces dentigerumycin, a cyclic depsipeptide with highly modified amino acids, to selectively inhibit the parasitic fungus (Escovopsis sp.).
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