Induction of a physiological memory in the cerebral cortex by stimulation of the nucleus basalis
Induction of a physiological memory in the cerebral cortex by stimulation of the nucleus basalis
复制标题
DOI：
10.1073/pnas.93.20.11219
复制
发表时间：
1996-10-01
影响因子：
11.1
通讯作者：
Weinberger, NM
中科院分区：
文献类型：
--
作者：
Bakin, JS;Weinberger, NM
在行为学习过程中产生的听觉皮层感受区可塑性可以被认为是生理记忆，因为它具有行为记忆的主要特征：关联性、专一性、快速习得和长期保持。为了研究基础前脑在感受野可塑性中的机制，我们在成年豚鼠中将刺激皮层下乙酰胆碱的主要来源--基底核与基底核配对。刺激基底核产生脑电去同步化，这种去同步化可被全身和皮质阿托品阻断。成对的纯音/基底核刺激，而不是不成对的刺激，诱导了类似于行为学习产生的感受野可塑性。因此，基底核的配对激活足以诱导感受野的可塑性，可能是通过皮质中的胆碱能作用。
Auditory cortical receptive field plasticity produced during behavioral learning may be considered to constitute ''physiological memory'' because it has major characteristics of behavioral memory: associativity, specificity, rapid acquisition, and long-term retention. To investigate basal forebrain mechanisms in receptive field plasticity, we paired a tone with stimulation of the nucleus basalis, the main subcortical source of cortical acetylcholine, in the adult guinea pig. Nucleus basalis stimulation produced electroencephalogram desynchronization that was blocked by systemic and cortical atropine. Paired tone/nucleus basalis stimulation, but not unpaired stimulation, induced receptive field plasticity similar to that produced by behavioral learning. Thus paired activation of the nucleus basalis is sufficient to induce receptive field plasticity, possibly via cholinergic actions in the cortex.