Determinants of left ventricular mass in early hypertension
Determinants of left ventricular mass in early hypertension
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DOI：
10.1016/s0895-7061(98)00132-0
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发表时间：
1998-10-01
影响因子：
3.2
通讯作者：
Tobe, SW
中科院分区：
文献类型：
--
作者：
Baker, B;O'Kelly, B;Tobe, SW
176 名未接受药物治疗的轻度高血压受试者（113 名男性，63 名女性）接受了 M 型超声心动图以确定左心室质量 (LVM) 和相对壁厚度 (RWT)、24 小时动态血压监测，并完成了测量婚姻和工作压力的标准化问卷。受试者年龄为 46 +/- 9 岁； 45.4% 的白天舒张压 < 90 mm Hg； 96.1% 的 LVM 结果在正常范围内。我们发现，婚姻困境和工作压力都不是 LVM 的决定因素。然而，分段回归方法揭示了 LVM 和 RWT 与动态血压之间关系的拐点：白天收缩压 131 毫米汞柱，夜间舒张压 83 毫米汞柱和 87 毫米汞柱。此外，我们发现 LVM 的变异性最好通过按高度（而不是体表面积）对 LVM 进行索引来解释。 Am J Hypertens 1998；11:1248-1251 (C) 1998 美国高血压杂志有限公司。
One hundred seventy-six unmedicated mildly hypertensive subjects (113 men, 63 women) underwent M-mode echocardiography to determine left ventricular mass (LVM) and relative wall thickness (RWT), 24-h ambulatory blood pressure monitoring, and completed standardized questionnaires measuring marital and job stress. Subjects were aged 46 +/- 9 years old; 45.4% had daytime diastolic blood pressure < 90 mm Hg; 96.1% of LVM results were in the normal range. We found that neither marital distress nor job strain was a determinant of LVM. However, a segmental regression approach revealed inflection points of 131 mm Hg systolic daytime blood pressure and 83 and 87 mm Hg nighttime diastolic blood pressure in the relation between LVM and RWT, respectively, and ambulatory BP. In addition, we found that the variability of LVM was best explained by indexing LVM by height, rather than body surface area. Am J Hypertens 1998;11:1248-1251 (C) 1998 American Journal of Hypertension, Ltd.