Overexpression levels of cripto-1 predict poor prognosis in patients with prostate cancer following radical prostatectomy
Overexpression levels of cripto-1 predict poor prognosis in patients with prostate cancer following radical prostatectomy
复制标题
cripto-1 的过表达水平预示前列腺癌根治术后患者预后不良
DOI：
10.3892/ol.2019.10555
复制
发表时间：
2019-09-01
期刊：
影响因子：
2.9
通讯作者：
Xu, Yong
中科院分区：
文献类型：
--
作者：
Liu, Yan;Wang, Jianan;Xu, Yong
CRIPTO-1(CR1)是一种表皮生长因子CRIPTO-1/FRL-1/隐性家族蛋白，已有报道在多种类型的恶性肿瘤中过表达。然而，CR-1在前列腺癌(PCa)中的临床作用仍不清楚。本研究的目的是探讨CR-1的表达与PCa临床病理特征及预后的关系。应用免疫组织化学方法检测138例PCa组织和67例良性前列腺增生症(BPH)组织中CR-1的表达。采用卡方检验分析PCa患者的临床病理特征与CR-1表达之间的关系。采用受试者工作特征(ROC)曲线和COX回归模型分析CR-1表达与无生化复发(BCR)生存率的关系。结果显示，CR-1在PCa组织中的表达明显高于在BPH组织中的表达。前列腺癌组织和细胞中CR-1mRNA的表达也显著高于BPH组织和正常RWPE-1细胞系(P
Overexpression of cripto-1 (CR-1), an epidermal growth factor-cripto-1/FRL-1/Cryptic family protein, has been reported in multiple types of malignancy. However, the clinical functions of CR-1 in prostate cancer (PCa) remain largely unclear. The objective of the present study was to investigate the association between CR-1 expression and the clinicopathological features and prognosis of PCa. CR-1 expression was evaluated in 138 PCa tissues and 67 benign prostate hyperplasia (BPH) tissues using immunohistochemistry. The association between the clinicopathological features of patients with PCa and CR-1 expression was analyzed using a chi(2) test. Receiver operating characteristic (ROC) curve and Cox regression model were used to analyze the association between CR-1 expression and biochemical recurrence (BCR)-free survival. It was revealed that the protein expression of CR-1 was markedly higher in PCa tissues than in BPH tissues. The mRNA expression of CR-1 in PCa tissue and cells was also significantly higher than in BPH tissue and the normal RWPE-1 prostate cell line (P