Somatic activation of β-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development
Somatic activation of β-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development
复制标题
DOI：
10.1038/ni0901-863
复制
发表时间：
2001-09-01
影响因子：
30.5
通讯作者：
von Boehmer, H
中科院分区：
文献类型：
--
作者：
Gounari, F;Aifantis, I;von Boehmer, H
T细胞因子I和淋巴细胞增强因子I的突变或消融表明Wnt通路参与胸腺细胞发育。Wnt通路的中心效应因子是β -连环蛋白，它在Wnt配体与卷曲受体结合时经历稳定化。我们在此报道，未成熟胸腺细胞中β -catenin的条件稳定导致缺乏α - β TCR的单阳性T细胞的产生，并且在缺乏前TCR信号传导和TCR选择的情况下发育。尽管活性β -catenin在没有TCR的情况下诱导分化，但与前TCR或α -TCR诱导的发育变化相比，其作用与增殖和存活减少有关。
Mutation or ablation of T cell factor I and lymphocyte enhancer factor I indicated involvement of the Wnt pathway in thymocyte development. The central effector of the Wnt pathway is beta -catenin, which undergoes stabilization upon binding of Wnt ligands to frizzled receptors. We report here that conditional stabilization of beta -catenin in immature thymocytes resulted in the generation of single positive T cells that lacked the alpha beta TCR and developed in the absence of pre-TCR signaling and TCR selection. Although active beta -catenin induced differentiation in the absence of TCRs, its action was associated with reduced proliferation and survival when compared to developmental changes induced by the pre-TCR or the alpha beta TCR.