5,7-Dihydroxytryptamine: regional brain concentrations following intraventricular administration to rats.
5,7-Dihydroxytryptamine: regional brain concentrations following intraventricular administration to rats.
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5,7-二羟色胺：大鼠脑室内给药后的区域脑浓度。
DOI：
10.1023/a:1012374923662
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发表时间：
2001
影响因子：
4.4
通讯作者：
Fernstrom,JD
中科院分区：
文献类型：
--
作者：
Choi,SJ;Patil,V;Fernstrom,JD
用5，7-二羟色胺（5，7-DHT 100 μg/侧脑室）注射成年雄性大鼠，测定注射后0、2、6、12和24小时脑干、下丘脑和大脑皮质中5，7-DHT 5-HT的含量。在6小时时，所有脑区的5，7-DHT水平从0小时值下降了99%。此后，5，7-DHT水平继续下降，在皮层，但不是在下丘脑或脑干;在24小时，但不是48小时，5，7-DHT峰值仍然是可测量的每个大脑区域检查。5，7-DHT给药后2-6小时，所有三个区域的血清素水平也显著下降。在24小时时，下丘脑和脑干5-HT水平下降>70%，大脑皮层下降<50%，低于对照值。这些研究结果的相关性单胺再摄取阻滞剂的保护作用进行了讨论。
The concentrations of 5,7-dihydroxytryptamine (5,7-DHT) and serotonin (5-HT) were measured in brainstem, hypothalamus and cerebral cortex 0, 2, 6, 12, and 24 hours following the bilateral, lateral ventricular injection of 5,7-DHT (100 μg/each ventricle) into adult male rats. At 6 hours, 5,7-DHT levels had decreased 99% from 0 hr values in all brain regions. Thereafter, 5,7-DHT levels continued to decline in cortex, but not in hypothalamus or brainstem; at 24 hr, but not 48 hr, 5,7-DHT peaks were still measurable in each brain region examined. Serotonin levels in all three regions also fell markedly by 2-6 hours after 5,7-DHT administration. At 24 hours, hypothalamus and brainstem 5HT levels had declined >70% and cerebral cortex ∼50% below control values. The relevance of these findings to the protective action of monoamine reuptake blockers is discussed.