Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies
Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies
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DOI：
10.1039/c7cc02059g
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发表时间：
2017-05-14
影响因子：
4.9
通讯作者：
Wang, Lai-Xi
中科院分区：
文献类型：
--
作者：
Cai, Hui;Orwenyo, Jared;Wang, Lai-Xi
我们在这里描述了新型多价HIV V3结构域糖肽的合成及其与广泛中和抗体PGT 128和10-1074的结合。我们的结合数据揭示了两种抗体识别抗原的不同模式，并进一步表明多价糖肽可以比单体糖肽更有效地模拟中和表位。
We describe here the synthesis of novel multivalent HIV V3 domain glycopeptides and their binding to broadly neutralizing antibodies PGT128 and 10-1074. Our binding data reveal a distinct mode of antigen recognition by the two antibodies and further suggest that multivalent glycopeptides could mimic the neutralizing epitopes more efficiently than the monomeric glycopeptide.