Fabrication of hollow poly-allylamine hydrochloride/poly-sodium styrene sulfonate microcapsules from microbubble templates
Fabrication of hollow poly-allylamine hydrochloride/poly-sodium styrene sulfonate microcapsules from microbubble templates
复制标题
DOI：
10.1039/c000071j
复制
发表时间：
2010-04
期刊：
影响因子：
3.4
通讯作者：
H. Daiguji;Eitaro Matsuoka;Satoshi Muto
中科院分区：
文献类型：
--
作者：
H. Daiguji;Eitaro Matsuoka;Satoshi Muto
由可生物降解聚合物制成的中空微胶囊作为超声造影剂和药物传递系统的载体受到了广泛的关注。一种中空的聚电解质微胶囊是这种应用的有希望的候选者之一。中空聚电解质微胶囊通常是在形成胶囊外壳后通过分解核心材料制成的。最近，Shchukin et . （D. G. Shchukin， K. Kohler， H. Mohwald and G. B. Sukhorukov, Angew.）化学。, Int。编辑，2005,44,3310-3314)和Winterhalter等（M. Winterhalter和a.f.p. Sonnen, Angew.）。化学。, Int。编辑，2006,45,2500-2502)提出了一种以微泡为模板制备中空聚电解质微胶囊的方法。在该方法中，通过超声发生器在表面活性剂溶液中形成稳定的微泡，然后在微泡表面吸附聚电解质，生成中空的聚电解质微胶囊。本研究提出了一种不使用表面活性剂制备中空聚丙烯胺/聚苯乙烯磺酸钠（PAH/PSS）微胶囊的新方法。在Na2CO3水溶液中，在一定的pH范围内，多环芳烃成为R-NHCOO−和R-NH3+的胶体颗粒。在此条件下，如果溶液中产生微泡，则吸附在微泡表面的胶体颗粒使微泡稳定。当PSS依次加入到溶液中时，PAH/PSS可以在微泡周围形成双分子层。我们成功制备了PAH/PSS空心微胶囊，并阐明了PAH胶体颗粒和PAH/PSS双分子层形成的条件。
Hollow microcapsules made of biodegradable polymers have attracted considerable attention as ultrasound contrast agents and carriers in drug delivery systems (DDSs). A hollow polyelectrolyte microcapsule is one of the promising candidates for such applications. Hollow polyelectrolyte microcapsules are normally fabricated by decomposing a core material after forming a capsule shell. Recently, Shchukin et al. (D. G. Shchukin, K. Kohler, H. Mohwald and G. B. Sukhorukov, Angew. Chem., Int. Ed., 2005, 44, 3310–3314) and Winterhalter et al. (M. Winterhalter and A. F. P. Sonnen, Angew. Chem., Int. Ed., 2006, 45, 2500–2502) proposed a fabrication method of hollow polyelectrolyte microcapsules using microbubbles as templates. In this method, stable microbubbles are formed in a surfactant solution by means of an ultrasound generator, and then, a polyelectrolyte is adsorbed on the microbubble surface, yielding hollow polyelectrolyte microcapsules. In this study, we proposed a new fabrication method for hollow poly-allylamine hydrochloride/poly-sodium styrene sulfonate (PAH/PSS) microcapsules without using surfactants. In a Na2CO3 aqueous solution, PAH becomes colloidal particles of R-NHCOO− and R-NH3+ within a certain pH range. Under such a condition, if microbubbles are generated in the solution, the colloidal particles adsorbed on the microbubble surface stabilize the microbubbles. When PSS is added to the solution sequentially, a bilayer of PAH/PSS can be formed around microbubbles. We successfully fabricated hollow PAH/PSS microcapsules by this method and elucidated the conditions required for the formation of colloidal particles of PAH and a bilayer of PAH/PSS.