FURTHER EVALUATION OF THE DEVELOPMENTAL TOXICITY OF TRIBUTYLTIN CHLORIDE IN RATS
FURTHER EVALUATION OF THE DEVELOPMENTAL TOXICITY OF TRIBUTYLTIN CHLORIDE IN RATS
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DOI：
10.1016/0300-483x(94)02920-p
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发表时间：
1995-02-27
期刊：
影响因子：
4.5
通讯作者：
OGAWA, Y
中科院分区：
文献类型：
--
作者：
EMA, M;KUROSAKA, R;OGAWA, Y
本研究的目的是进一步评价三丁基锡对大鼠的发育毒性。妊娠大鼠分别于妊娠第7~9天、第10~12天、第13~15天经胃管给予25、50、100 mg/kg的三氯联苯。TBTCl25和50 mg/kg组和100 mg/kg组在第7-9天和第10-12天植入后丢失发生率显著增加，但在第13-15天没有明显增加。在治疗7-9天后，观察到畸形胎儿的发生率没有显著增加。10-12天100 mg/kg和13-15天25、50、100 mg/kg剂量组畸形儿发生率显著增加。最常见的畸形是腭裂。结果表明，给药时不同发育阶段的小鼠发育异常表现不同，具有一定的发育阶段特异性，具有致畸潜能。
The objective of this study was to further evaluate the developmental toxicity of tributyltin chloride (TBTCl) in rats. Pregnant rats were given TBTCl by gastric intubation at a dose of 25, 50 or 100 mg/kg on days 7-9, days 10-12 or days 13-15 of pregnancy. A significant increase in the incidence of post-implantation loss was found in the groups treated with TBTCl on days 7-9 at 25 and 50 mg/kg and on days 10-12 at 100 mg/kg, but not in the groups treated with TBTCl on days 13-15. No significant increase in the incidence of malformed fetuses was observed after treatment with TBTCl on days 7-9. A significantly increased incidence of malformed fetuses was detected when TBTCl was given on days 10-12 at 100 mg/kg and on days 13-15 at 25, 50 and 100 mg/kg. The most predominant malformation was cleft palate. It could be concluded that the manifestation of deviant development induced by TBTCl varies with the developmental stage at the time of administration and TBTCl possesses teratogenic potential with developmental phase specificity.