ABSENCE OF INTESTINAL MAST-CELL RESPONSE IN CONGENITALLY ATHYMIC MICE DURING TRICHINELLA-SPIRALIS INFECTION
ABSENCE OF INTESTINAL MAST-CELL RESPONSE IN CONGENITALLY ATHYMIC MICE DURING TRICHINELLA-SPIRALIS INFECTION
复制标题
DOI：
10.1038/264258a0
复制
发表时间：
1976-01-01
期刊：
影响因子：
64.8
通讯作者：
ELGERSMA, A
中科院分区：
文献类型：
--
作者：
RUITENBER, EJ;ELGERSMA, A
在实验室啮齿类动物线虫感染的肠道阶段，在肠道粘膜中发现了多种细胞类型，包括肥大细胞和球白细胞1 -4。在肠腔中存在的线虫或渗透到肠粘膜中的线虫刺激后，肠肥大细胞的数量增加1，4。接下来，肥大细胞侵入绒毛的上皮衬里，排出分泌产物，包括组胺，并转变为上皮内小球白细胞1，5。肥大细胞分泌产物的释放由IgE抗体介导6。迄今为止，还没有确凿的证据表明分泌产物在蠕虫的排出中起作用。
DURING the intestinal phase of nematode infections in laboratory rodents a variety of cell types is found in the gut mucosa, including mast cells and globule leukocytes1–4. After stimulation by the nematodes present either in the intestinal lumen or penetrated into the gut mucosa, the number of intestinal mast cells increases1,4. Next, mast cells invade the epithelial lining of the villi, discharge secretory products, including histamine, and change into the intra-epithelial globule leukocytes1,5. Release of mast cell secretory products is mediated by IgE antibody6. No conclusive evidence has as yet been presented, that the secretory products have a role in the expulsion of the worms.