In vitro Short-Time Killing Activity of Povidone-Iodine (Isodine® Gargle) in the Presence of Oral Organic Matter
In vitro Short-Time Killing Activity of Povidone-Iodine (Isodine® Gargle) in the Presence of Oral Organic Matter
复制标题
存在口腔有机物时聚维酮碘（Isodine® 漱口水）的体外短时杀菌活性
作者：
A. Yoneyama;Masaki Shimizu;M. Tabata;Junko Yashiro;T. Takata;M. Hikida
为了评价聚维酮-碘口服杀菌剂（PVP-I）对口腔细菌性感染性疾病的临床疗效，我们研究了口服有机物对PVP-I体外杀灭活性的影响。此外，我们使用健康志愿者的漱口水和漱口水样本，比较了PVP-I与其他口腔防腐剂的体外短时杀伤活性。当使用任何漱口水和漱口水样品时，标准浓度（0.23-0.47%）或更低浓度的PVP-I在口腔有机物存在的15-60秒内杀死耐甲氧西林金黄色葡萄球菌（MRSA）和铜绿假单胞菌，包括多重耐药菌株。0.02% benzethonium chloride （BEC）和0.002% chlorhexidine gluconate （CHG）对含MRSA和P. aeruginosa（包括耐多药菌株）的漱口水和含漱液在60 s后也没有效果。上述结果表明，标准浓度的PVP-I体外杀灭活性几乎不受口腔有机物的影响，含有PVP-I的漱口水或漱口液的杀菌活性比BEC和CHG更强。虽然在本研究中获得的是健康个体的漱口水样本，但如果鼓励适当的浓度和使用，PVP-I可用于预防各种疾病患者的感染。
In order to estimate the clinical efficacy of a povidone-iodine oral antiseptic (PVP-I) on oral bacterial infectious diseases, we studied the effect of oral organic matter on the in vitro killing activity of PVP-I. In addition, we compared the in vitro short-time killing activity of PVP-I with those of other oral antiseptics using mouth-washing and gargling samples collected from healthy volunteers. When any of the mouth-washing and gargling samples was used, the standard (0.23–0.47%) or lower concentrations of PVP-I killed methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa, including multidrug-resistant strains, within 15–60 s in the presence of oral organic matter. 0.02% benzethonium chloride (BEC) and 0.002% chlorhexidine gluconate (CHG) did not show effects against MRSA and P. aeruginosa (including multidrug-resistant strains) in mouth-washing and gargling samples even after 60 s. The above-mentioned results show that the in vitro killing activity of the standard concentration of PVP-I was hardly affected by the oral organic matter and that a mouth-washing or gargling solution containing PVP-I has a stronger bactericidal activity than BEC and CHG. Although mouth-washing and gargling samples were obtained from healthy individuals in this study, PVP-I may be used for protection against infections in patients with various diseases, if proper concentrations and usage are encouraged.