Specificity of Repetition Priming: The Role of Chemical Coding
Specificity of Repetition Priming: The Role of Chemical Coding
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DOI：
10.1523/jneurosci.4562-14.2015
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发表时间：
2015-04-22
影响因子：
5.3
通讯作者：
Cropper, Elizabeth C.
中科院分区：
文献类型：
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作者：
Friedman, Allyson K.;Weiss, Klaudiusz R.;Cropper, Elizabeth C.
我们在一个可处理的模型系统中研究重复启动的刺激特异性；大头蛇的摄食网以前的研究主要集中在行为的一个方面，是改变在摄取启动，radula打开。当两种调节肽[摄食回路激活肽（FCAP）和脑肽-2 (CP-2)]从胆碱能命令样神经元脑颊间神经元2释放时，会发生radula开口的启动。FCAP/CP-2对radula开口运动神经元的影响是cAMP介导的。本实验旨在确定FCAP/CP-2和cAMP是否也参与了不相容活动（即在排血运动程序期间）中radula打开的启动。当食道神经的传入过程触发运动程序时，会诱发出血性启动。我们证明了分泌性启动不是FCAP/CP-2介导的。相反，它是由一种不相关的肽（小心脏活性肽）诱导的，它发挥pkc介导的作用。因此，我们的数据表明，不同的进食运动程序是通过不同的细胞间和细胞内物质的作用启动的。我们认为这说明了重复启动的刺激特异性。不同的刺激激活不同的中枢模式发生器输入。这些输入释放不同的调制器，从而诱导不同功能的运动程序。
We investigate stimulus specificity of repetition priming in a tractable model system; the feeding network of Aplysia. Previous studies primarily focused on an aspect of behavior that is altered during ingestive priming, radula opening. Priming of radula opening occurs when two modulatory peptides [feeding circuit activating peptide (FCAP) and cerebral peptide-2 (CP-2)] are released from the cholinergic command-like neuron cerebral buccal interneuron 2. Effects of FCAP/CP-2 on radula opening motor neurons are cAMP mediated. The present experiments sought to determine whether FCAP/CP-2 and cAMP are also involved in the priming of radula opening during an incompatible activity, i.e., during egestive motor programs. Egestive priming is induced when motor programs are triggered by afferents with processes in the esophageal nerve. We demonstrate that egestive priming is not FCAP/CP-2 mediated. Instead, it is induced by an unrelated peptide (small cardioactive peptide), which exerts PKC-mediated effects. Our data, therefore, suggest that different feeding motor programs are primed via actions of different sets of intercellular and intracellular substances. We suggest that this accounts for the stimulus specificity that can be characteristic of repetition priming. Different stimuli activate different central pattern generator inputs. These inputs release different modulators, which induce functionally distinct motor programs.