The history of rubella and rubella vaccination leading to elimination
The history of rubella and rubella vaccination leading to elimination
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DOI：
10.1086/505950
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发表时间：
2006-11-01
影响因子：
11.8
通讯作者：
Plotkin, Stanley A.
中科院分区：
文献类型：
--
作者：
Plotkin, Stanley A.
先天性风疹综合征（CRS）在20世纪40年代被发现，风疹病毒在20世纪60年代初被分离出来，风疹疫苗在同一个十年末变得可用。系统接种风疹疫苗，通常与麻疹结合使用，已经消除了一些发达国家的先天性和后天性感染，最近是美国，这一点已被本增刊中的文章所证实。本文总结了CRS的临床综合征，疫苗的开发过程，导致消除的历史，以及在更大范围内消除的可能性。
Congenital rubella syndrome (CRS) was discovered in the 1940s, rubella virus was isolated in the early 1960s, and rubella vaccines became available by the end of the same decade. Systematic vaccination against rubella, usually in combination with measles, has eliminated both the congenital and acquired infection from some developed countries, most recently the United States, as is confirmed by the articles in this supplement. The present article summarizes the clinical syndrome of CRS, the process by which the vaccine was developed, and the history leading up to elimination, as well as the possible extension of elimination on a wider scale.