Stage-Specific Regulation of Oligodendrocyte Development by Wnt/β-Catenin Signaling
Stage-Specific Regulation of Oligodendrocyte Development by Wnt/β-Catenin Signaling
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Wnt/β-连环蛋白信号传导对少突胶质细胞发育的阶段特异性调节
DOI：
10.1523/jneurosci.0311-14.2014
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发表时间：
2014-06-18
影响因子：
5.3
通讯作者：
Qiu, Mengsheng
中科院分区：
文献类型：
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作者：
Dai, Zhong-Min;Sun, Shuhui;Qiu, Mengsheng
少突胶质细胞是形成髓磷脂的神经胶质细胞，包裹着中枢神经系统神经元的轴突。最近的研究表明，Wnt/β-连环蛋白信号在少突胶质细胞发育和髓磷脂形成中发挥重要作用。然而，关于 Wnt 信号成分在少突胶质细胞分化和分化中的具体功能，存在相互矛盾的报道。在本研究中，我们证明在神经胶质细胞生成之前激活神经祖细胞中的β-连环蛋白会抑制小鼠少突胶质细胞祖细胞（OLP）的生成。一旦 OLP 形成，β-连环蛋白就成为少突胶质细胞分化所必需的。相反，β-连环蛋白信号传导的破坏会导致少突胶质细胞成熟的显着延迟。这些发现表明 Wnt/β-连环蛋白途径以阶段依赖性方式调节少突胶质细胞的发育。
Oligodendrocytes are myelin-forming glia that ensheath the axons of neurons in the CNS. Recent studies have revealed that Wnt/beta-catenin signaling plays important roles in oligodendrocyte development and myelin formation. However, there are conflicting reports on the specific function of Wnt signaling components in oligodendrocyte specification and differentiation. In the present study, we demonstrate that activation of beta-catenin in neural progenitor cells before gliogenesis inhibits the generation of oligodendrocyte progenitors (OLPs) in mice. Once OLPs are formed, beta-catenin becomes necessary for oligodendrocyte differentiation. Disruption of beta-catenin signaling instead leads to a significant delay of oligodendrocyte maturation. These findings suggest that Wnt/beta-catenin pathway regulates oligodendrocyte development in a stage-dependent manner.