Signaling mechanism of the netrin-1 receptor DCC in axon guidance.
Signaling mechanism of the netrin-1 receptor DCC in axon guidance.
复制标题
Netrin-1受体DCC的信号传导机制在Axon引导中。
DOI：
10.1016/j.pbiomolbio.2015.04.001
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发表时间：
2015-09
影响因子：
3.8
通讯作者：
Wang JH
中科院分区：
文献类型：
--
作者：
Finci L;Zhang Y;Meijers R;Wang JH
DCC（结直肠癌删除）是一种单次跨膜蛋白，属于免疫球蛋白超家族。它最初被鉴定为一种预后肿瘤标志物，随后被发现是 netrin-1 的受体。 DCC 在轴突引导以及许多其他重要的细胞过程中发挥着关键作用。这篇综述描述了 DCC 结构生物学的当前进展，重点介绍了 DCC 如何参与 netrin-1 作为化学引诱剂和轴突引导驱避剂的双重功能（称为双功能）。还概述了其他 DCC 配体和 DCC 细胞质尾信号传导机制的观点。
DCC (Deleted in Colorectal Cancer) is a single-pass transmembrane protein that belongs to the immunoglobulin superfamily. It was originally identified as a prognostic tumor marker and then subsequently found to be a receptor for netrin-1. DCC plays a key role in axon guidance and also in a number of other important cellular processes. This review describes the current progress of the structural biology of DCC with an emphasis on how DCC is involved in the dual functionality of netrin-1 as a chemo-attractant as well as a repellent in axon guidance, referred to as bi-functionality. A perspective about other DCC ligands and the signaling mechanism of the cytoplasmic tail of DCC is also recapitulated.