Ezrin gene, coding for a membrane-cyto skeleton linker protein, is regionally expressed in the developing mouse neuroepithelium
Ezrin gene, coding for a membrane-cyto skeleton linker protein, is regionally expressed in the developing mouse neuroepithelium
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DOI：
10.1016/j.modgep.2004.03.007
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发表时间：
2004-10-01
影响因子：
1.2
通讯作者：
Martinez, S
中科院分区：
文献类型：
--
作者：
Gimeno, L;Corradi, A;Martinez, S
Ezrin是Ezrin，Radixin，Moesin(ERM)蛋白家族的成员，被认为是细胞骨架和质膜之间的连接物。Ezrin调节细胞-细胞和细胞-基质的相互作用，在调节上皮细胞的黏附、运动和形态方面发挥作用。Ezrin和ERM家族其他成员的表达变化也在脑瘤中观察到。在这里，我们报道了Ezrin在小鼠神经发育过程中的表达模式，从早期到出生后阶段。在年轻和中期妊娠胚胎中，Ezrin表达于神经管顶板、脉络丛的推定区域和一些精确的脑室上皮区域。这些结构域分布在基底和鼻翼神经上皮区，其中一些与钙粘附素的表达有关。在妊娠后期和出生后阶段，Ezrin在成熟的脉络丛上保持表达，在成熟脑的增殖区检测到微弱的表达。(C)2004爱思唯尔B.V.保留所有权利。
Ezrin is a member of the Ezrin, Radixin, Moesin (ERM) proteins family that are proposed to act as linkers between the cytoskeleton and plasma membrane. Ezrin regulates cell-cell and cell-matrix interactions playing a role in the regulation of cellular adhesion, movement and morphology in epithelia. Alterations in the expression of Ezrin and other members of ERM family have also been observed in brain tumours. Here we report the expression pattern of Ezrin during mouse neural development, from early stages to postnatal stages. In young and middle gestation embryos, Ezrin is expressed in the roof plate of the neural tube, in the presumptive domain of the choroidal plexus, and in some precise domains of ventricular epithelium. These domains are distributed in basal and alar neuroepithelial regions, some of them in relation to the expression of cadherins. At later gestation and postnatal stages, Ezrin expression is maintained on the mature choroidal plexus and is weakly detected in the proliferative regions of the mature brain. (C) 2004 Elsevier B.V. All rights reserved.