Epidemiology, diagnosis and treatment of acute promyelocytic leukemia in children: the experience in china.
Epidemiology, diagnosis and treatment of acute promyelocytic leukemia in children: the experience in china.
复制标题
DOI：
10.4084/mjhid.2012.012
复制
发表时间：
2012
影响因子：
3.2
通讯作者：
Zhu X
中科院分区：
文献类型：
--
作者：
Zhang L;Zhu X
急性早幼粒细胞白血病（Acute promyelocytic leukemia， APL）是急性髓性白血病的一种亚型，其特征是骨髓中异常早幼粒细胞的积累、严重的出血倾向和染色体易位t（15;17）或变体的存在。APL是20年前最致命的白血病类型，目前的治疗策略是高度可治愈的。有证据表明，APL的发病率在不同种族之间存在差异，遗传因素在APL的病因学中起作用。儿童与成人在APL中存在一定的差异。许多发展中国家现有的儿童数据有限，这表明早期死亡率很高，长期存活率很低。化疗期间出血和感染导致的死亡、复发和放弃治疗是APL儿童和成人治疗失败的主要原因。中国儿童APL的治疗现状尚未得到全面的描述。本文介绍了中国儿童APL的流行病学和治疗情况。此外，我们回顾了在中国对其临床表现和结果的调查结果。
Acute promyelocytic leukemia (APL) is the subtype of acute myeloid leukemia characterized by an accumulation of abnormal promyelocytes in bone marrow, a severe bleeding tendency and the presence of the chromosomal translocation t(15;17) or variants. APL, the most fatal type of leukemia two decades ago, is highly curable with current treatment strategies. There is evidence that the incidence of APL varies across ethnic groups and that genetic factors play a role in the etiology of APL. And there are some difference between children and adults in APL. The limited data of children available in many developing countries suggest that the rate of early mortality is high and that long-term survival is poor. Death from bleeding and infection during chemotherapy, relapse and treatment abandonment are among the main cause of treatment failure in APL children as well in adults. The status of children APL treatment in China has not been described in general. Here we describe the epidemiology and treatment of APL in children in China. In addition, we review the results of a survey of its clinical manifestations and outcome in China.