Normal findings on noninvasive cardiac assessment and the prediction of heart failure: The Multi-Ethnic Study of Atherosclerosis (MESA).
Normal findings on noninvasive cardiac assessment and the prediction of heart failure: The Multi-Ethnic Study of Atherosclerosis (MESA).
复制标题
无创心脏评估和心力衰竭预测的正常结果：动脉粥样硬化的多种族研究 (MESA)。
DOI：
10.1016/j.ijcard.2017.08.078
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发表时间：
2017
影响因子：
3.5
通讯作者：
Soliman,ElsayedZ
中科院分区：
文献类型：
--
作者：
Broughton,StephenT;O'Neal,WesleyT;Al-Mallah,Mouaz;Bluemke,DavidA;Heckbert,SusanR;Lima,JoaoAC;Soliman,ElsayedZ
BackgroundIt is unknown if normal findings on noninvasive cardiac assessment are able to identify individuals who are low risk for developing heart failure (HF).MethodsWe examined if normal findings on the routine electrocardiogram (ECG) and cardiac magnetic resonance imaging (MRI) were able to identify individuals who are low risk for developing HF in 4986 (mean age = 62 ± 10 years; 52% women; 39% White; 13% Chinese-American; 26% Black; 22% Hispanic) participants from the Multi-Ethnic Study of Atherosclerosis who were free of clinically apparent HF at baseline. A normal ECG was defined as the absence of major abnormalities by Minnesota Code Classification, and a normal MRI was defined as absence of structural abnormalities and systolic dysfunction.ResultsThere were 3988 (80%) participants with normal findings at baseline on both ECG and MRI, 894 (18%) who had either a normal ECG or normal MRI, and 104 (2%) who had abnormal findings on ECG and MRI. Over a median follow-up of 12.2 years, 177 (3.6%) HF events occurred. Normal ECG (HR = 0.41, 95%CI = 0.29, 0.56) and MRI (HR = 0.32, 95%CI = 0.23, 0.45) were each associated with lower risk of HF compared with abnormal, and their combination was associated with a lower HF risk (HR = 0.13, 95%CI = 0.08, 0.21) than either in isolation.ConclusionNormal findings on noninvasive cardiac assessment identify individuals in whom the risk of HF is low. Further studies are needed to explore the utility of this low-risk profile in HF prevention strategies.
