Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells.
Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells.
复制标题
DOI：
10.1093/nar/gks1111
复制
发表时间：
2013-01
影响因子：
14.9
通讯作者：
Garnett MJ
中科院分区：
文献类型：
--
作者：
Yang W;Soares J;Greninger P;Edelman EJ;Lightfoot H;Forbes S;Bindal N;Beare D;Smith JA;Thompson IR;Ramaswamy S;Futreal PA;Haber DA;Stratton MR;Benes C;McDermott U;Garnett MJ
癌症基因组的改变强烈影响对治疗的临床反应，并且在许多情况下是对药物反应的有效生物标志物。癌症药物敏感性基因组学（GDSC）数据库（www.cancerRxgene.org）是有关癌细胞药物敏感性和药物反应分子标志物信息的最大公共资源。数据可以不受限制地自由获取。GDSC目前包含近75000个实验的药物敏感性数据，描述了近700种癌细胞系对138种抗癌药物的反应。为了鉴定药物反应的分子标志物，将细胞系药物敏感性数据与从癌症体细胞突变目录数据库获得的大型基因组数据集整合，包括关于癌症基因中的体细胞突变、基因扩增和缺失、组织类型和转录数据的信息。GDSC数据的分析是通过一个门户网站进行的，该门户网站专注于基于特定抗癌药物或癌症基因的查询来识别药物敏感性的分子生物标志物。数据的图形表示与相关资源的链接贯穿始终，所有数据集都可以完全下载。GDSC提供了一个独特的资源，整合了大型药物敏感性和基因组数据集，以促进发现癌症治疗的新治疗生物标志物。
Alterations in cancer genomes strongly influence clinical responses to treatment and in many instances are potent biomarkers for response to drugs. The Genomics of Drug Sensitivity in Cancer (GDSC) database (www.cancerRxgene.org) is the largest public resource for information on drug sensitivity in cancer cells and molecular markers of drug response. Data are freely available without restriction. GDSC currently contains drug sensitivity data for almost 75 000 experiments, describing response to 138 anticancer drugs across almost 700 cancer cell lines. To identify molecular markers of drug response, cell line drug sensitivity data are integrated with large genomic datasets obtained from the Catalogue of Somatic Mutations in Cancer database, including information on somatic mutations in cancer genes, gene amplification and deletion, tissue type and transcriptional data. Analysis of GDSC data is through a web portal focused on identifying molecular biomarkers of drug sensitivity based on queries of specific anticancer drugs or cancer genes. Graphical representations of the data are used throughout with links to related resources and all datasets are fully downloadable. GDSC provides a unique resource incorporating large drug sensitivity and genomic datasets to facilitate the discovery of new therapeutic biomarkers for cancer therapies.
登录
查看更多内容
影响因子：
158.5
作者：
Druker, Brian J.;Guilhot, Francois;Larson, Richard A.
通讯作者：
Larson, Richard A.
影响因子：
64.8
作者：
Garnett, Mathew J.;Edelman, Elena J.;Heidorn, Sonja J.;Greenman, Chris D.;Dastur, Anahita;Lau, King Wai;Greninger, Patricia;Thompson, I. Richard;Luo, Xi;Soares, Jorge;Liu, Qingsong;Iorio, Francesco;Surdez, Didier;Chen, Li;Milano, Randy J.;Bignell, Graham R.;Tam, Ah T.;Davies, Helen;Stevenson, Jesse A.;Barthorpe, Syd;Lutz, Stephen R.;Kogera, Fiona;Lawrence, Karl;McLaren-Douglas, Anne;Mitropoulos, Xeni;Mironenko, Tatiana;Thi, Helen;Richardson, Laura;Zhou, Wenjun;Jewitt, Frances;Zhang, Tinghu;O'Brien, Patrick;Boisvert, Jessica L.;Price, Stacey;Hur, Wooyoung;Yang, Wanjuan;Deng, Xianming;Butler, Adam;Choi, Hwan Geun;Chang, JaeWon;Baselga, Jose;Stamenkovic, Ivan;Engelman, Jeffrey A.;Sharma, Sreenath V.;Delattre, Olivier;Saez-Rodriguez, Julio;Gray, Nathanael S.;Settleman, Jeffrey;Futreal, P. Andrew;Haber, Daniel A.;Stratton, Michael R.;Ramaswamy, Sridhar;McDermott, Ultan;Benes, Cyril H.
通讯作者：
Benes, Cyril H.
影响因子：
14.9
作者：
Forbes SA;Bindal N;Bamford S;Cole C;Kok CY;Beare D;Jia M;Shepherd R;Leung K;Menzies A;Teague JW;Campbell PJ;Stratton MR;Futreal PA
通讯作者：
Futreal PA
影响因子：
14.9
作者：
UniProt Consortium
通讯作者：
UniProt Consortium
影响因子：
64.8
作者：
Barretina, Jordi;Caponigro, Giordano;Stransky, Nicolas;Venkatesan, Kavitha;Margolin, Adam A.;Kim, Sungjoon;Wilson, Christopher J.;Lehar, Joseph;Kryukov, Gregory V.;Sonkin, Dmitriy;Reddy, Anupama;Liu, Manway;Murray, Lauren;Berger, Michael F.;Monahan, John E.;Morais, Paula;Meltzer, Jodi;Korejwa, Adam;Jane-Valbuena, Judit;Mapa, Felipa A.;Thibault, Joseph;Bric-Furlong, Eva;Raman, Pichai;Shipway, Aaron;Engels, Ingo H.;Cheng, Jill;Yu, Guoying K.;Yu, Jianjun;Aspesi, Peter, Jr.;de Silva, Melanie;Jagtap, Kalpana;Jones, Michael D.;Wang, Li;Hatton, Charles;Palescandolo, Emanuele;Gupta, Supriya;Mahan, Scott;Sougnez, Carrie;Onofrio, Robert C.;Liefeld, Ted;MacConaill, Laura;Winckler, Wendy;Reich, Michael;Li, Nanxin;Mesirov, Jill P.;Gabriel, Stacey B.;Getz, Gad;Ardlie, Kristin;Chan, Vivien;Myer, Vic E.;Weber, Barbara L.;Porter, Jeff;Warmuth, Markus;Finan, Peter;Harris, Jennifer L.;Meyerson, Matthew;Golub, Todd R.;Morrissey, Michael P.;Sellers, William R.;Schlegel, Robert;Garraway, Levi A.
通讯作者：
Garraway, Levi A.