Molecular imaging for evaluation of synovitis associated with osteoarthritis: a narrative review.
Molecular imaging for evaluation of synovitis associated with osteoarthritis: a narrative review.
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分子成像用于评估与骨关节炎相关的滑膜炎：叙述性回顾。
DOI：
10.1186/s13075-023-03258-6
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发表时间：
2024-01-16
影响因子：
4.9
通讯作者：
中科院分区：
文献类型：
--
作者：
最近的证据强调了低度滑膜炎症在骨关节炎（OA）进展中的作用。通过成像方式检测到的OA关节的炎症滑膜与OA的后续进展相关。从这个意义上说，通过影像学检测和量化OA滑膜炎可能对预测OA进展以及提高我们对OA进展的理解有价值。在几种成像模式中，分子成像如正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）具有使组织的细胞或亚细胞事件可视化的优点。根据所使用的放射性示踪剂，分子成像方法可以潜在地检测和可视化滑膜炎症的各个方面。本文综述了近年来影像学检查在炎症和OA滑膜炎诊断中的应用进展，并重点介绍了新型放射性示踪剂。本文总结了近年来用于检测和量化炎症和OA滑膜炎的影像学检查方法，包括超声检查（US）、磁共振成像（MRI）和分子成像。已经开发了特异性靶向炎症组分的新型放射性示踪剂。这些示踪剂可能在检测OA的炎症滑膜方面显示出希望，并有助于扩大我们对OA进展的理解。
Recent evidence highlights the role of low-grade synovial inflammation in the progression of osteoarthritis (OA). Inflamed synovium of OA joints detected by imaging modalities are associated with subsequent progression of OA. In this sense, detecting and quantifying synovitis of OA by imaging modalities may be valuable in predicting OA progressors as well as in improving our understanding of OA progression. Of the several imaging modalities, molecular imaging such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT) has an advantage of visualizing the cellular or subcellular events of the tissues. Depending on the radiotracers used, molecular imaging method can potentially detect and visualize various aspects of synovial inflammation. This narrative review summarizes the recent progresses of imaging modalities in assessing inflammation and OA synovitis and focuses on novel radiotracers. Recent studies about imaging modalities including ultrasonography (US), magnetic resonance imaging (MRI), and molecular imaging that were used to detect and quantify inflammation and OA synovitis are summarized. Novel radiotracers specifically targeting the components of inflammation have been developed. These tracers may show promise in detecting inflamed synovium of OA and help in expanding our understanding of OA progression.
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DOI：
10.1002/art.39731
发表时间：
2016-10
期刊：
Arthritis & rheumatology (Hoboken, N.J.)
影响因子：
--
作者：
Collins JE;Losina E;Nevitt MC;Roemer FW;Guermazi A;Lynch JA;Katz JN;Kent Kwoh C;Kraus VB;Hunter DJ
通讯作者：
Hunter DJ
影响因子：
27.4
作者：
Atukorala I;Kwoh CK;Guermazi A;Roemer FW;Boudreau RM;Hannon MJ;Hunter DJ
通讯作者：
Hunter DJ
影响因子：
3.2
作者：
Bahce I;Huisman MC;Verwer EE;Ooijevaar R;Boutkourt F;Vugts DJ;van Dongen GA;Boellaard R;Smit EF
通讯作者：
Smit EF
影响因子：
4.6
作者：
Chou, Ching-Heng;Jain, Vaibhav;Kraus, Virginia B.
通讯作者：
Kraus, Virginia B.
DOI：
10.2967/jnumed.108.060186
发表时间：
2009-07
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Fujimura Y;Zoghbi SS;Simèon FG;Taku A;Pike VW;Innis RB;Fujita M
通讯作者：
Fujita M