Predatory aggression, but not maternal or intermale aggression, is associated with high voluntary wheel-running behavior in mice
Predatory aggression, but not maternal or intermale aggression, is associated with high voluntary wheel-running behavior in mice
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DOI：
10.1016/s0018-506x(03)00140-5
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发表时间：
2003-09-01
影响因子：
3.5
通讯作者：
Garland, T
中科院分区：
文献类型：
--
作者：
Gammie, SC;Hasen, NS;Garland, T
在四个重复品系的小鼠中检查了捕食性（对蟋蟀）、雄性间和母体攻击性，这些小鼠已被选择性地饲养用于高轮跑（S）和四个随机饲养的对照品系（C）。在第18代，在捕食和雄性间的侵略的个体差异显着一致，在四个试验天，但捕食和雄性间的侵略是不相关的，在个人水平和八行之间的手段。攻击蟋蟀的潜伏期在S系作为一个组显着降低。雄性间的侵略，但是，没有不同的S和C线。S线的体重显着较小，但没有显着差异，无论是睾丸质量或血浆睾酮。在第28代和第30代，分别，S和C线没有显着差异，无论是母亲或intermale侵略。然而，发现个体品系之间的母性攻击性存在显著差异，并且一个S品系表现出极高的平均攻击时间（5分钟测试>120秒）。母亲和intermale侵略之间没有相关的八行手段或在个体变异水平。总的来说，我们的结果表明：（1）捕食性攻击与主动轮跑在遗传水平上呈正相关;（2）捕食性攻击与雄性间攻击在遗传水平上无关;（3）母性攻击与雄性间攻击在遗传水平上不密切相关。掠夺性攻击，多巴胺和车轮运行行为之间可能存在的关系进行了讨论。(C)2003年爱思唯尔公司All rights reserved.
Predatory (towards crickets), intermale, and maternal aggression were examined in four replicate lines of mice that had been selectively bred for high wheel-running (S) and in four random-bred control lines (C). In generation 18, individual differences in both predatory and intermale aggression were significantly consistent across four trial days, but predatory and intermale aggression were uncorrelated both at the individual level and among the eight line means. Latencies to attack crickets were significantly lower in S lines as a group. Intermale aggression, however, did not differ between S and C lines. S lines were significantly smaller in body mass, but did not differ in either testes mass or plasma testosterone. In generations 28 and 30, respectively, S and C lines did not differ in either maternal or intermale aggression. However, significant differences among the individual lines were found for maternal aggression, and one S line exhibited an extremely high mean time of aggression (>120 sec for a 5-min test). Maternal and intermale aggression were not correlated among the eight line means or at the level of individual variation. Overall, our results suggest: (1) predatory aggression and voluntary wheel-running are positively related at the genetic level; (2) predatory and intermale aggression are unrelated at a genetic level; and (3) maternal and intermale aggression are not tightly related at the genetic level. Possible relationships between predatory aggression, dopamine, and wheel-running behavior are discussed. (C) 2003 Elsevier Inc. All rights reserved.