Non-Contrast-Enhanced Perfusion and Ventilation Assessment of the Human Lung by Means of Fourier Decomposition in Proton MRI
Non-Contrast-Enhanced Perfusion and Ventilation Assessment of the Human Lung by Means of Fourier Decomposition in Proton MRI
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DOI：
10.1002/mrm.22031
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发表时间：
2009-09-01
影响因子：
3.3
通讯作者：
Schad, Lothar R.
中科院分区：
文献类型：
--
作者：
Bauman, Grzegorz;Puderbach, Michael;Schad, Lothar R.
评价局部肺灌注通气对肺部疾病的诊断和随访具有重要的临床价值。在这项工作中，提出了一种新的非对比增强功能肺部MRI（不依赖于静脉或吸入对比剂）的方法。在1.5T全身MR扫描仪上实现了二维（2D）稳定进动（TrueFISP）脉冲序列（TR/TE = 1.9 ms/0.8 ms，采集时间[TA] = 112 ms/图像）的真快速成像。成像方案包括198组肺图像，冠状面和矢状面成像速率为3.33张/秒。没有使用心电图或呼吸触发。采用非刚性图像配准算法对呼吸运动进行补偿。快速数据采集允许观察相应肺区域相对于心脏和呼吸频率的强度变化。在沿时域进行傅里叶分析后，使用两个频率对应的两条谱线计算灌注和通风加权图像。所述方法应用于具有临床相关性的志愿者和患者的初步研究，以获得非对比增强灌注和通气数据。中华医学杂志（英文版），2009。(C) 2009 Wiley-Liss, Inc。
Assessment of regional lung perfusion and ventilation has significant clinical value for the diagnosis and follow-up of pulmonary diseases. In this work a new method of non-contrast-enhanced functional lung MRI (not dependent on intravenous or inhalative contrast agents) is proposed. A two-dimensional (2D) true fast imaging with steady precession (TrueFISP) pulse sequence (TR/TE = 1.9 ms/0.8 ms, acquisition time [TA] = 112 ms/image) was implemented on a 1.5T whole-body MR scanner. The imaging protocol comprised sets of 198 lung images acquired with an imaging rate of 3.33 images/s in coronal and sagittal view. No electrocardiogram (ECG) or respiratory triggering was used. A nonrigid image registration algorithm was applied to compensate for respiratory motion. Rapid data acquisition allowed observing intensity changes in corresponding lung areas with respect to the cardiac and respiratory frequencies. After a Fourier analysis along the time domain, two spectral lines corresponding to both frequencies were used to calculate the perfusion- and ventilation-weighted images. The described method was applied in preliminary studies on volunteers and patients showing clinical relevance to obtain non-contrast-enhanced perfusion and ventilation data. Magn Reson Med 62:656-664, 2009. (C) 2009 Wiley-Liss, Inc.