LIPGENE: an integrated approach to tackling the metabolic syndrome
LIPGENE: an integrated approach to tackling the metabolic syndrome
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DOI：
10.1079/pns2005441
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发表时间：
2005-07-01
影响因子：
7
通讯作者：
Nugent, A
中科院分区：
文献类型：
--
作者：
Buttriss, J;Nugent, A
肥胖、超重和2型糖尿病的流行率在欧洲所有地区都在增加。肥胖已经是司空见惯的事，影响10-20%的男性和10-25%的女性，到2010年，大约3100万人口将需要治疗糖尿病及其相关并发症，包括“代谢综合征”（一组心血管风险因素）。由于这些趋势的直接结果，预计欧洲的相关保健和社会福利费用将上升到经济上不可持续的水平。需要有效的战略来解决这一重大的公共卫生问题，减少对医疗管理的依赖。这些问题是由欧盟委员会资助的LIPGENE（FOOD-CT-2003-505944）的重点，该项目将调查饮食成分和基因组在慢性疾病（如代谢综合征）发展中的相互作用，并将利用新技术确定新的解决方案。LIPGENE联盟由遍布欧洲的25个研究中心组成。这项为期五年的工作方案的特点包括在欧洲八个城市进行一项重大的人类营养干预研究，开发一种天然富含长链n-3脂肪酸的可持续植物油产品，并确定一项喂养奶牛的方案，使牛奶具有更有利的脂肪酸组成。其他工作包将提供与代谢综合征相关的当前和未来医疗保健成本的详细经济分析，以及消费者态度的分析。还有一个与该项目有关的传播方案，包括会议、讲习班和相关出版物。
The prevalence of obesity, overweight and type 2 diabetes are increasing in all regions of Europe. Obesity is already commonplace, affecting 10-20% of men and 10-25% of women, and by 2010 approximately 31 million of the population will require treatment for diabetes and its related complications, including the 'metabolic syndrome' (a cluster of cardiovascular risk factors). Associated health and social welfare costs are expected to rise to economically unsustainable levels in Europe as a direct result of these trends. Effective strategies are needed to tackle this major public health problem and to decrease dependence on medical management. These issues are the focus of LIPGENE (FOOD-CT-2003-505944), funded by the European Commission, which will investigate the interactions between dietary constituents and the genome in the development of chronic diseases, such as the metabolic syndrome, and will utilise new technologies to identify novel solutions. The LIPGENE consortium comprises twenty-five research centres across Europe. Features of the 5-year work programme include a major human nutrition intervention study in eight European cities, development of a sustainable vegetable oil product naturally rich in long-chain n-3 fatty acids, and identification of a protocol for feeding dairy cows that will result in milk with a more favourable fatty acid composition. Other work packages will provide a detailed economic analysis of the current and future healthcare costs associated with the metabolic syndrome, and an analysis of consumer attitudes. There is also a dissemination programme associated with the project that features conferences, workshops and associated publications.