Evaluation of indoor residual spraying with the pyrrole insecticide chlorfenapyr against pyrethroid-susceptible Anopheles arabiensis and pyrethroid-resistant Culex quinquefasciatus mosquitoes
Evaluation of indoor residual spraying with the pyrrole insecticide chlorfenapyr against pyrethroid-susceptible Anopheles arabiensis and pyrethroid-resistant Culex quinquefasciatus mosquitoes
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DOI：
10.1016/j.trstmh.2010.07.008
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发表时间：
2010-10-01
影响因子：
2.2
通讯作者：
Rowland, M. W.
中科院分区：
文献类型：
--
作者：
Oxborough, R. M.;Kitau, J.;Rowland, M. W.
溴虫腈是一种吡咯杀虫剂，具有独特的非神经作用模式。虫螨腈对拟除虫菊酯敏感和抗性冈比亚按蚊的室内生物测定比较。和致倦库蚊表明不太可能发生操作性交叉抗性（抗性比率在0和2.1之间）。在坦桑尼亚北方一个水稻灌溉区的试验小屋中进行了三次溴虫腈室内滞留喷洒试验。阿拉伯的。每天进行蚊子收集，以评估产品性能，主要是在死亡率方面。在第二个试验中，测试了250 mg/m2和500 mg/m2溴虫腈在6个月内的残留效力。两种剂量对C. quinquefasciatus，而A. 250 mg/m2的阿拉伯胶杀灭48%，500 mg/m2的为41%;试验结束时的死亡率与开始时一样高。在第三次试验中，将250毫克/平方米的溴虫腈与30毫克/平方米的拟除虫菊酯类甲氯氰菊酯进行了比较。溴虫腈对A.这两种杀虫剂都能杀死50%的蚊子。溴虫腈杀灭的拟除虫菊酯抗性C。致倦库蚊（56%），而顺式氯氰菊酯（17%）。溴虫腈有可能成为有限的公共卫生杀虫剂库的重要补充，用于室内残留控制A。阿拉伯蚊子和对拟除虫菊酯有抗药性的蚊子。(C)2010年皇家热带医学和卫生学会。由爱思唯尔有限公司出版。保留所有权利。
Chlorfenapyr is a pyrrole insecticide with a unique non-neurological mode of action. Laboratory bioassays of chlorfenapyr comparing the mortality of pyrethroid-susceptible and -resistant Anopheles gambiae s.s. and Culex quinquefasciatus mosquitoes indicated that operational cross-resistance is unlikely to occur (resistance ratio ranged between 0 and 2.1). Three trials of chlorfenapyr indoor residual spraying were undertaken in experimental huts in an area of rice irrigation in northern Tanzania that supports breeding of A. arabiensis. Daily mosquito collections were undertaken to assess product performance primarily in terms of mortality. In the second trial, 250 mg/m(2) and 500 mg/m(2) chlorfenapyr were tested for residual efficacy over 6 months. Both dosages killed 54% of C. quinquefasciatus, whilst for A. arabiensis 250 mg/m(2) killed 48% compared with 41% for 500 mg/m(2); mortality was as high at the end of the trial as at the beginning. In the third trial, 250 mg/m(2) chlorfenapyr was compared with the pyrethroid alpha-cypermethrin dosed at 30 mg/m(2). Chlorfenapyr performance was equivalent to the pyrethroid against A. arabiensis, with both insecticides killing 50% of mosquitoes. Chlorfenapyr killed a significantly higher proportion of pyrethroid-resistant C. quinquefasciatus (56%) compared with alpha-cypermethrin (17%). Chlorfenapyr has the potential to be an important addition to the limited arsenal of public health insecticides for indoor residual control of A. arabiensis and pyrethroid-resistant species of mosquito. (C) 2010 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.