Intestinal absorption of several beta-lactam antibiotics. II. Absorption characteristics of amino-penicillins and amino-cephalosporins.
Intestinal absorption of several beta-lactam antibiotics. II. Absorption characteristics of amino-penicillins and amino-cephalosporins.
复制标题
几种β-内酰胺抗生素的肠道吸收。
DOI：
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发表时间：
1979
影响因子：
1.7
通讯作者：
T. Arita
中科院分区：
文献类型：
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作者：
K. Umeniwa;O. Ogino;K. Miyazaki;T. Arita
为探讨头孢氨苄、头孢定、阿莫西林等抗生素在胃肠道的吸收特性，采用循环灌注法、肠袢法和肠囊外翻法研究了这些抗生素在大鼠肠道的吸收机制。头孢拉定被证明是主动运输的。其他抗生素似乎沿着浓度梯度在肠道中扩散。这些药物在肠道组织中的蓄积特别明显，尤其是头孢氨苄和头孢定，在低温下这三种药物的蓄积都被显著抑制。这些观察结果为已知的这些抗生素的快速吸收提供了实验基础。
In order to investigate the absorption characteristics of cephalexin, cephradine, and amoxicillin, which are well absorbed from the gastrointestinal tract, the mechanisms of intestinal absorption of these antibiotics in rats were examined using the recirculating perfusion technique, the loop method, and the everted gut sac technique. Cephradine was shown to be actively transported. Other antibiotics appeared to diffuse across the intestine down a concentration gradient. The accumulations of these drugs, in the intestinal tissue, especially cephalexin and cephradine, were particularly marked, and the accumulation of each of these three drugs was significantly inhibited at low temperature. These observations provide an experimental basis for the known rapid absorption of these antibiotics.