Development and Physiological Regulation of Intestinal Lipid Absorption. I. Development of intestinal lipid absorption: cellular events in chylomicron assembly and secretion
Development and Physiological Regulation of Intestinal Lipid Absorption. I. Development of intestinal lipid absorption: cellular events in chylomicron assembly and secretion
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DOI：
10.1152/ajpgi.00189.2007
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发表时间：
2007-09-01
影响因子：
4.5
通讯作者：
Black, Dennis D.
中科院分区：
文献类型：
--
作者：
Black, Dennis D.
新生哺乳动物必须有效地吸收膳食脂肪，主要是三酰基甘油，并产生乳糜微粒将这种脂质传递到周围组织。肠细胞乳糜微粒组装的细胞机制最近已被阐明，其在未成熟肠道中的调节数据也开始出现。本文综述了参与乳糜微粒组装的关键蛋白：载脂蛋白B- 48、微粒体甘油三酯转移蛋白和载脂蛋白A- IV。最近的研究支持载脂蛋白A- IV通过促进更大颗粒的产生来促进乳糜微粒的分泌。这些蛋白在某种程度上受到调节，以最大限度地提高新生儿肠道的脂质吸收能力。
The newborn mammal must efficiently absorb dietary fat, predominantly as triacylglycerol, and produce chylomicrons to deliver this lipid to peripheral tissues. The cellular mechanisms involved in enterocyte chylomicron assembly have recently been elucidated, and data on their regulation in the immature gut are beginning to emerge. This review focuses on key proteins involved in chylomicron assembly: apolipoprotein B- 48, microsomal triglyceride transfer protein, and apolipoproten A- IV. Recent studies support a role for apolipoprotein A- IV in enhancing chylomicron secretion by promoting production of larger particles. These proteins are regulated in a manner to maximize the lipid absorptive capacity of the newborn intestine.