The importance of animal influenza for human disease
The importance of animal influenza for human disease
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DOI：
10.1016/s0264-410x(02)00123-8
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发表时间：
2002-05-15
期刊：
影响因子：
5.5
通讯作者：
Webster, RG
中科院分区：
文献类型：
--
作者：
Webster, RG
流感是一种由不断变化的RNA病毒引起的人畜共患疾病，因此需要持续监测以更新人类疫苗。我们的知识表明，流感的间歇性大流行起源于低等动物和鸟类中的流感病毒或流感病毒的基因片段。这些流行病可能是温和的，也可能是灾难性的。虽然我们对“动物”流感病毒的生态学和分子特性有了很多了解，但我们还没有一个全面的国际监测系统。1918年西班牙发生的源自低等动物的流感大流行，以及最近香港发生的H5 NI禽流感事件，都提醒我们流感是一种新兴疾病。21世纪世纪的挑战是积累必要的动物流感病毒流行病学数据，以便设计一个国际监测系统。这些流行病学数据可能为如何减少流感的种间传播提供线索。H5 NI禽流感事件发生后，香港把水禽与其他“陆上”家禽分开饲养，显示畜牧业的做法可能影响流感病毒在物种间的传播。(C)2002年由Elsevier Science Ltd.出版
Influenza is a zoonotic disease caused by a constantly varying RNA virus resulting in a need for continuous surveillance to update human vaccines. Our knowledge indicates that the intermittent pandemics of influenza originate from influenza viruses or gene segments from influenza viruses in lower animals and birds. These pandemics can be mild to catastrophic. While we have learned a great deal about the ecology and molecular properties of "animal" influenza viruses, we do not have a system for comprehensive international surveillance. The 1918 Spanish influenza pandemic that originated from lower animals and the recent H5NI bird flu incident in Hong Kong serves to remind us that influenza is an emerging disease. The challenge for the 21st century is to accumulate the necessary epidemiological data on animal influenza viruses so that an international surveillance system can be devised. This epidemiological data may provide clues on how to reduce interspecies transmission of influenza. The separation of aquatic birds from other "land based" domestic poultry in Hong Kong after the H5NI bird flu incident indicates that animal husbandry practices could influence the interspecies transmission of influenza viruses. (C) 2002 Published by Elsevier Science Ltd.