In utero exposure to environmental lead and manganese and neurodevelopment at 2 years of age
In utero exposure to environmental lead and manganese and neurodevelopment at 2 years of age
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DOI：
10.1016/j.envres.2013.03.003
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发表时间：
2013-05-01
影响因子：
8.3
通讯作者：
Chen, Pau-Chung
中科院分区：
文献类型：
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作者：
Lin, Ching-Chun;Chen, Yu-Chuan;Chen, Pau-Chung
背景与目的：锰、铅、砷、汞是环境中常见的神经毒性金属。然而，产前暴露于低剂量的神经毒性金属和儿童神经发育之间的关系尚不清楚。本研究的目的是探讨在子宫内暴露于环境中的神经毒性金属和神经发育在2 years age.Methods：本研究的人口来自台湾出生面板研究之间的关系。我们纳入了230对不吸烟的母亲，没有任何职业暴露和他们的独生子女。使用结构式问卷获得有关妊娠期间暴露的信息，并使用电感耦合等离子体质谱法分析脐带血样本中的锰、铅、砷和汞水平。我们使用婴儿和幼儿综合发育量表（CDIIT）来评估每个孩子在2岁时的发育状况，我们使用线性回归模型来检查子宫内暴露于环境金属和神经发育的关联。结果：本研究脐带血样本中锰、铅、砷和汞的中位浓度为47.90 μ g/L（范围17.88-106.85 μ g/L）、11.41 μ g/L（范围0.16-43.22 μ g/L）、4.05 μ g/L（范围1.50-12.88 μ g/L）和12.17 μ g/L（范围1.53-64.87 μ g/L）。在调整了母亲年龄、婴儿性别、怀孕期间和分娩后的环境烟草烟雾、家庭观察测量环境清单结果以及脐带血中的砷和汞水平后，我们发现，锰和铅水平高于第75百分位数与总体（β =-7.03，SE =2.65，P=0.0085），认知（beta=-8.19，SE =3.17，P=0.0105），语言障碍者（beta=-6.81，SE =2.73，P=0.0133）。子宫内暴露于环境锰和铅可能与2岁时的神经发育有不良关系，脐带血中的锰和铅水平之间存在交互作用，可能会加重这种影响。(C)2013 Elsevier Inc. All rights reserved.
Background and objective: Manganese, lead, arsenic and mercury are common neurotoxic metals in the environment. Nonetheless, the relationship between prenatal exposure to low doses of neurotoxic metals and neurodevelopment in children is not clear. The objective of this study was to explore the relationship between in utero exposure to environmental neurotoxic metals and neurodevelopment at 2 years of age.Methods: The population of this study came from the Taiwan Birth Panel Study. We included 230 pairs of non-smoking mothers without any occupational exposure and their singleton full-term children. The information about exposure during pregnancy was obtained using a structured questionnaire, and the manganese, lead, arsenic and mercury levels in umbilical cord blood samples were analyzed using inductively coupled plasma mass spectrometry. We used the Comprehensive Developmental Inventory for Infants and Toddlers (CDIIT) to evaluate the developmental status of each child at 2 years of age, and we examined the association of in utero exposure to environmental metals and neurodevelopment using linear regression models.Results: The median concentrations of manganese, lead, arsenic and mercury in the cord blood samples in this study were 47.90 mu g/L (range, 17.88-106.85 mu g/L), 11.41 mu g/L (range 0.16-43.22 mu g/L), 4.05 mu g/L (range, 1.50-12.88 mu g/L) and 12.17 mu g/L (range, 1.53-64.87 mu g/L), respectively. After adjusting for maternal age, infant gender, environmental tobacco smoke during pregnancy and after delivery, Home Observation for Measurement of the Environment Inventory results, and arsenic and mercury levels in cord blood, we found that manganese and lead levels above the 75th percentile had a significant adverse association with the overall (beta=-7.03, SE=2.65, P=0.0085), cognitive (beta=-8.19, SE=3.17, P=0.0105), and language quotients (beta=-6.81, SE=2.73, P=0.0133) of the CDIIT.Conclusions: In utero exposure to environmental manganese and lead may have an adverse association with neurodevelopment at 2 years of age, and there is an interaction effect between the manganese and lead levels in the cord blood that could aggravate the effect. (C) 2013 Elsevier Inc. All rights reserved.