Factors affecting the chemical exchange saturation transfer of Creatine as assessed by 11.7 T MRI
Factors affecting the chemical exchange saturation transfer of Creatine as assessed by 11.7 T MRI
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DOI：
10.1007/s12194-014-0303-0
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发表时间：
2015-01-01
影响因子：
1.6
通讯作者：
Murase, Kenya
中科院分区：
文献类型：
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作者：
Saito, Shigeyoshi;Mori, Yuki;Murase, Kenya
化学交换饱和转移（CEST）是一种新的对比度增强方法，用于成像人体内的外源性或内源性物质，如肌酸（Cr），酰胺质子和谷氨酸。场强的增加有利于CEST成像，因为增加的化学位移和更长的纵向弛豫时间（T-1）。在高场磁共振成像（MRI）中，建立和评估CEST效应对于优化磁化转移（MT）饱和射频（RF）脉冲非常重要。在这项研究中，通过适当选择MT饱和RF脉冲，使用11.7 T MRI，在pH模型中评估了不同浓度下CEST对Cr的影响。结果表明，CEST效率随外加饱和射频脉冲功率的增加而逐渐增加，并受饱和射频脉冲个数和带宽的影响。然而，溢出效应观察到较高的饱和RF脉冲功率。总之，我们在MT饱和RF脉冲的优化条件下成功地进行了体外Cr CEST成像。
Chemical exchange saturation transfer (CEST) is a new contrast enhancement approach for imaging exogenous or endogenous substances such as creatine (Cr), amide protons, and glutamate in the human body. An increase in field strength is beneficial for CEST imaging because of the increased chemical shift and longer longitudinal relaxation time (T-1). In high-field magnetic resonance imaging (MRI), establishing and evaluating the CEST effect is important for optimizing the magnetization transfer (MT) saturation radio frequency (RF) pulses. In this study, the CEST effect on Cr was evaluated at different concentrations in pH phantoms by appropriately selecting MT saturation RF pulses using 11.7 T MRI. The results showed that the CEST efficiency increased gradually with increasing applied saturation RF pulse power and that it was affected by the number of saturation RF pulses and their bandwidths. However, spillover effects were observed with higher saturation RF pulse powers. In conclusion, we successfully performed in vitro Cr CEST imaging under optimized conditions of MT saturation RF pulses.