Biological interactions of carbon-based nanomaterials: From coronation to degradation.
Biological interactions of carbon-based nanomaterials: From coronation to degradation.
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DOI：
10.1016/j.nano.2015.11.011
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发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
Fadeel B
中科院分区：
文献类型：
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作者：
Bhattacharya K;Mukherjee SP;Gallud A;Burkert SC;Bistarelli S;Bellucci S;Bottini M;Star A;Fadeel B
包括单壁和多壁碳纳米管、氧化石墨烯、富勒烯和纳米金刚石的碳基纳米材料是用于诸如药物递送和成像的医学中的各种应用的潜在候选者。然而，纳米材料的生物医学应用的成功翻译是基于对这些材料的生物相互作用的详细了解。事实上，不应忽视蛋白质、脂质和其他生物分子的所谓生物冠对体内纳米材料命运的潜在影响。免疫活性细胞对碳基纳米材料的酶促降解是生物冠相互作用的一个特例，对此类纳米材料的医疗用途具有重要意义。在本综述中，我们重点介绍了碳基纳米材料的新兴生物医学应用。我们讨论了最近的研究纳米材料的“加冕”，这是如何影响生物分布和靶向沿着与碳基纳米材料的酶降解的研究，以及这些生物相互作用的纳米材料的表面改性的作用。本综述讨论了碳基纳米材料的生物相互作用，重点是生物冠的形成，生物降解，生物分布和靶向各种生物医学应用。
Carbon-based nanomaterials including single- and multi-walled carbon nanotubes, graphene oxide, fullerenes and nanodiamonds are potential candidates for various applications in medicine such as drug delivery and imaging. However, the successful translation of nanomaterials for biomedical applications is predicated on a detailed understanding of the biological interactions of these materials. Indeed, the potential impact of the so-called bio-corona of proteins, lipids, and other biomolecules on the fate of nanomaterials in the body should not be ignored. Enzymatic degradation of carbon-based nanomaterials by immune-competent cells serves as a special case of bio-corona interactions with important implications for the medical use of such nanomaterials. In the present review, we highlight emerging biomedical applications of carbon-based nanomaterials. We discuss recent studies on nanomaterial ‘coronation’ and how this impacts on biodistribution and targeting along with studies on the enzymatic degradation of carbon-based nanomaterials, and the role of surface modification of nanomaterials for these biological interactions. The present review discusses biological interactions of carbon-based nanomaterials, focusing on bio-corona formation, biodegradation, and biodistribution and targeting for various biomedical applications.