Allele-specific targeting of microRNAs to HLA-G and risk of asthma
Allele-specific targeting of microRNAs to HLA-G and risk of asthma
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DOI：
10.1086/521200
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发表时间：
2007-10-01
影响因子：
9.8
通讯作者：
Ober, Carole
中科院分区：
文献类型：
--
作者：
Tan, Zheng;Randall, Glenn;Ober, Carole
HLA-G是一种非经典的I类HLA分子，具有重要的免疫调节特性。以前，我们确定HLA-G为哮喘易感基因，并发现儿童患哮喘的风险由儿童的HLA-G基因型和母亲的情感状态决定。在这里，我们报告了HLA-G 3'非翻译区的SNP，它影响了三种microRNA（miRNAs）对该基因的靶向作用，我们认为这些miRNAs的等位基因特异性靶向作用至少部分解释了我们早期对HLA-G和哮喘风险的观察。
HLA-G is a nonclassic, class I HLA molecule that has important immunomodulatory properties. Previously, we identified HLA-G as an asthma-susceptibility gene and discovered that the risk of asthma in a child was determined by both the child's HLA-G genotype and the mother's affection status. Here we report a SNP in the 3' untranslated region of HLA-G that influences the targeting of three microRNAs (miRNAs) to this gene, and we suggest that allele-specific targeting of these miRNAs accounts, at least in part, for our earlier observations on HLA-G and the risk of asthma.