Oxysterols regulate differentiation of mesenchymal stem cells: Pro-bone and anti-fat
Oxysterols regulate differentiation of mesenchymal stem cells: Pro-bone and anti-fat
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DOI：
10.1359/jbmr.040115
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发表时间：
2004-05-01
影响因子：
6.2
通讯作者：
Parhami, F
中科院分区：
文献类型：
--
作者：
Kha, HT;Basseri, B;Parhami, F
多能间充质干细胞可以在成体生物体中经历谱系特异性分化。然而，对驱动这种分化的因素和机制的理解是有限的。我们展示了特异性氧固醇调节间充质干细胞向成骨细胞的谱系特异性分化同时抑制其成脂分化的新能力。这种影响可能对骨质疏松症的干预具有重要意义。
Pluripotent mesenchymal stem cells can undergo lineage-specific differentiation in adult organisms. However, understanding of the factors and mechanisms that drive this differentiation is limited. We show the novel ability of specific oxysterols to regulate lineage-specific differentiation of mesenchymal stem cells into osteogenic cells while inhibiting their adipogenic differentiation. Such effects may have important implications for intervention with osteoporosis.