Changes in brain and behavior during food-based decision-making following treatment of anorexia nervosa.
Changes in brain and behavior during food-based decision-making following treatment of anorexia nervosa.
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神经性厌食症治疗后基于食物的决策过程中大脑和行为的变化。
DOI：
10.1186/s40337-021-00402-y
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发表时间：
2021-04-17
影响因子：
4.1
通讯作者：
Steinglass JE
中科院分区：
文献类型：
--
作者：
Foerde K;Walsh BT;Dalack M;Daw N;Shohamy D;Steinglass JE
神经性厌食症是一种死亡率很高的严重疾病，在很大程度上是由于严重和持续限制食物摄入造成的。一个关键的挑战是确定与适应不良饮食行为相关的大脑机制，以及它们是否会随着治疗而改变。这项研究测试了神经性厌食症中与食物选择相关的尾状核激活是否会随着治疗而变化。健康女性（n = 29）和神经性厌食症住院女性（n = 24），年龄18至40岁，在两个时间点的fMRI扫描期间完成了食物选择任务。在患者中，手术发生在入院时（时间1），并在患者体重恢复正常后（时间2）再次进行。健康对照组以与患者组匹配的间隔进行两次测试。选择相关的尾状核激活进行了评估，在每个时间点，使用参数分析的先验区域的利益。在患者中，选择高脂肪食物的比例并没有随着时间的推移而改变（p> 0.47），但治疗后尾状核神经活动的减少与高脂肪食物选择的增加有关（r23 =-0.43，p = 0.037）。在时间1，神经性厌食症女性与健康对照女性的选择相关尾状核激活不同（健康对照：M = 0.15 ± 0.87，神经性厌食症：M = 0.70 ± 1.1，t51 =-2.05，p = 0.045），但在时间2时未发生（健康对照：M = 0.18 ± 1.0，神经性厌食症：M = 0.37 ± 0.99，t51 =-0.694，p = 0.49）。与治疗前的健康对照个体相比，神经性厌食症个体的尾状核活动与食物决策的相关性更强，接受治疗的神经性厌食症个体的尾状核参与减少与高脂肪食物选择增加相关。这些发现强调了开发更成功地改变饮食行为和指导饮食行为的神经机制的治疗方法的必要性。在线版本包含补充材料，可在10.1186/s40337-021-00402-y获得。
Anorexia nervosa is a severe illness with a high mortality rate, driven in large part by severe and persistent restriction of food intake. A critical challenge is to identify brain mechanisms associated with maladaptive eating behavior and whether they change with treatment. This study tested whether food choice-related caudate activation in anorexia nervosa changes with treatment. Healthy women (n = 29) and women hospitalized with anorexia nervosa (n = 24), ages 18 to 40 years, completed a Food Choice Task during fMRI scanning at two timepoints. Among patients, procedures occurred upon hospital admission (Time 1) and again after patients had gained to normal weight (Time 2). Healthy controls were tested twice at an interval group-matched to patients. Choice-related caudate activation was assessed at each timepoint, using parametric analyses in an a priori region of interest. Among patients, the proportion of high-fat foods selected did not change over time (p’s > 0.47), but decreased neural activity in the caudate after treatment was associated with increased selection of high-fat foods (r23 = − 0.43, p = 0.037). Choice-related caudate activation differed among women with anorexia nervosa vs healthy control women at Time 1 (healthy control: M = 0.15 ± 0.87, anorexia nervosa: M = 0.70 ± 1.1, t51 = − 2.05, p = 0.045), but not at Time 2 (healthy control: M = 0.18 ± 1.0, anorexia nervosa: M = 0.37 ± 0.99, t51 = − 0.694, p = 0.49). Caudate activity was more strongly associated with decisions about food among individuals with anorexia nervosa relative to healthy comparison individuals prior to treatment, and decreases in caudate engagement among individuals with anorexia nervosa undergoing treatment were associated with increases in high-fat food choices. The findings underscore the need for treatment development that more successfully alters both eating behavior and the neural mechanisms that guide it. The online version contains supplementary material available at 10.1186/s40337-021-00402-y.
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影响因子：
5.7
作者：
Bartra, Oscar;McGuire, Joseph T.;Kable, Joseph W.
通讯作者：
Kable, Joseph W.
影响因子：
3.8
作者：
Barr DJ
通讯作者：
Barr DJ
评估健康个体中食物选择任务的重测可靠性。
影响因子：
5.4
作者：
Foerde K;Gianini L;Wang Y;Wu P;Shohamy D;Walsh BT;Steinglass JE
通讯作者：
Steinglass JE
影响因子：
158.5
作者：
Attia, Evelyn;Walsh, B. Timothy
通讯作者：
Walsh, B. Timothy
影响因子：
5.7
作者：
Bernardoni, Fabio;King, Joseph A.;Ehrlich, Stefan
通讯作者：
Ehrlich, Stefan