Dietary habits and pancreatic cancer risk in a cohort of middle-aged and elderly Japanese
Dietary habits and pancreatic cancer risk in a cohort of middle-aged and elderly Japanese
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DOI：
10.1207/s15327914nc5601_6
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发表时间：
2006-01-01
影响因子：
2.9
通讯作者：
Ishibashi, Teruo
中科院分区：
文献类型：
--
作者：
Lin, Yingsong;Kikuchi, Shogo;Ishibashi, Teruo
在日本，很少有流行病学研究探讨饮食与胰腺癌之间的关联。在日本癌症风险评估协作队列研究中，我们评估了饮食因素（包括肉类、蔬菜和水果的摄入量）与胰腺癌死亡风险之间的关系。在 1988 年至 1990 年间建立的原始队列中，截至 1999 年 12 月 31 日，对 40-79 岁的 46,465 名男性和 64,327 名女性进行了随访。在 1,042,608 人年的随访中，我们记录了 300 人死于胰腺癌。基线调查时使用包含 33 项食物频率的问卷来评估饮食摄入量。 Cox 比例风险模型用于估计胰腺癌死亡与食物摄入频率相关的相对风险。我们没有观察到肉类摄入量与胰腺癌风险之间的总体关联。除了男性高水果摄入量导致的风险降低 50% 之外，我们没有发现蔬菜和水果摄入量与胰腺癌风险之间存在其他显着的负相关关系。吸烟并没有改变与饮食习惯的关联。我们的研究表明，大量食用泡菜和野生食用植物（主要是蕨菜）可能与胰腺癌风险增加有关；然而这一发现应该在其他流行病学研究中得到证实。
Few epidemiological studies have examined associations between diet and pancreatic cancer in Japan. In the Japan Collaborative Cohort Study for Evaluation of Cancer Risk, we evaluated the relationship between dietary factors, including meat, vegetable, and fruit intake, and the risk of pancreatic cancer deaths. Among the original cohort established between 1988 and 1990, 46,465 men and 64,327 women aged 40-79 yr were followed-up through December 31,1999. During 1,042,608 person-years of follow-up, we documented 300 deaths from pancreatic cancer. A 33-item food-frequency questionnaire was used to assess dietary intake at the baseline survey. Cox proportional-hazards models were used to estimate the relative risks of pancreatic cancer death in relation to the intake frequency of food items. We did not observe an overall association between meat intake and pancreatic cancer risk. Except for a 50% decrease in risk associated with high fruit intake among men, we did not find other significant inverse relationships between vegetable and fruit intake and pancreatic cancer risk. Smoking did not modify the associations with dietary habits. Our study suggested that high consumption of pickles and wild edible plants, mainly bracken, might be related to increased pancreatic cancer risk; however this finding should be confirmed in other epidemiological studies.