Presymptomatic DNA testing for Huntington's disease.
Presymptomatic DNA testing for Huntington's disease.
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亨廷顿病症状前 DNA 检测。
DOI：
10.1176/jnp.1.2.195
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Folstein,SE
中科院分区：
文献类型：
--
作者：
Brandt,J;Quaid,KA;Folstein,SE
研究了53名参与研究项目的个体的数据，该研究项目为患有亨廷顿病（HD）的风险为50%的成年人提供症状前基因检测。目的是确定（1）告知人们他们的HD遗传状态的精神，心理和社会后果，（2）预测试特征是否可以区分那些适应良好或不适应他们的状态的人，以及（3）干预措施是否可以减轻病态的心理和社会后果。9名最终检测HD标记物阳性的Ss在SCL-90（修订版）的9个量表中的5个量表上报告了比后来检测阴性的29名Ss更大的心理困扰，这表明HD基因可能具有亚临床表现。基因检测的标记状态和伦理影响的披露心理和社会后果进行了讨论。（PsycINFO数据库记录（c）2016阿帕，保留所有权利）
Examined data on 53 individuals who participated in a research program that offered presymptomatic genetic testing to adults at 50% risk for developing Huntington's disease (HD). The aim is to determine (1) psychiatric, psychological, and social consequences of informing people of their HD genetic status,(2) whether pretest characteristics can discriminate those who adapt well or poorly to their status, and (3) whether interventions can mitigate morbid psychological and social outcomes. Nine Ss who eventually tested positive for the HD marker reported greater psychological distress on 5 out of 9 scales of the SCL-90 (Revised) than the 29 Ss who later tested negative, suggesting that the HD gene may have subclinical manifestations. Psychological and social outcomes from disclosure of marker status and ethical implications of genetic testing are discussed.(PsycINFO Database Record (c) 2016 APA, all rights reserved)