Pathological and physiological hypertrophies are regulated by distinct gene programs
Pathological and physiological hypertrophies are regulated by distinct gene programs
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DOI：
10.1097/hjr.0b013e32833158a2
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发表时间：
2009-12-01
影响因子：
--
通讯作者：
Ellingsen, Oyvind
中科院分区：
文献类型：
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作者：
Beisvag, Vidar;Kemi, Ole Johan;Ellingsen, Oyvind
背景本研究的目的是调查发生在进展和建立的生理和病理性心脏肥大的变化，通过微阵列技术和功能annotation.Design和方法心肌梗死导致心力衰竭诱导大鼠，与冠状动脉结扎后1，3，7，14，42，和92天的动物死亡。第二组进行日常跑步机运动和杀害1，4，24，48小时后，一个单一的运动回合，或28或56天的运动training.Results生理性肥大与较少的转录变化比病理性肥大，表明转录后和翻译调控可能更重要。两种类型的肥大之间的主要区别是，心肌梗死与脂肪酸代谢相关基因的下调有关，而运动训练后没有发生这种变化。因此，脂肪酸代谢可以区分不利的适应不良肥大有益的适应性hypertrophy.Conclusion本研究指出，特定的基因和基因类相关的生物过程，可能是重要的，在这些良好的特点大鼠模型的生理和病理性心脏肥大。欧洲心脏病学会康复杂志16：690-697（C）2009
Background This study aims to investigate changes that occur during progression and establishment of physiological and pathological cardiac hypertrophy, by microarray technology and functional annotations.Design and methods Myocardial infarction leading to heart failure was induced in rats, with animals killed 1, 3, 7,14, 42, and 92 days after coronary artery ligation. A second group was subjected to daily treadmill exercise and killed 1, 4, 24, and 48 h after a single exercise bout, or after 28 or 56 days of exercise training.Results Physiological hypertrophy was associated with less transcriptional alternation than pathological hypertrophy, indicating that posttranscriptional and translational regulation may be more important. The main difference between the two types of hypertrophy was that myocardial infarction was associated with downregulation of genes related to fatty acid metabolism, whereas no such change occurred after exercise training. Thus, fatty acid metabolism may distinguish adverse maladaptive hypertrophy from beneficial adaptive hypertrophy.Conclusion This study points to specific genes and gene classes related to biological processes that may be important in these well-characterized rat models of physiological and pathological cardiac hypertrophy. Eur J Cardiovasc Prev Rehabil 16:690-697 (C) 2009 The European Society of Cardiology