Myelopolyneuropathy and pancytopenia due to copper deficiency and high zinc levels of unknown origin II. The denture cream is a primary source of excessive zinc
Myelopolyneuropathy and pancytopenia due to copper deficiency and high zinc levels of unknown origin II. The denture cream is a primary source of excessive zinc
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DOI：
10.1016/j.neuro.2009.08.008
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发表时间：
2009-11-01
期刊：
影响因子：
3.4
通讯作者：
Brewer, George J.
中科院分区：
文献类型：
--
作者：
Hedera, Peter;Peltier, Amanda;Brewer, George J.
与低铜血症和高锌血症相关的中枢和周围神经系统的神经变性已被广泛认识，但高锌的起源仍然未知。最近有人建议义齿膏作为锌的一种可能来源，但仅义齿固定剂导致这种综合征的频率尚不清楚。我们分析了 11 名患有进行性骨髓多发性神经病和不明原因低铜血症伴高锌血症的患者体内锌过量的根源。这些患者进行了详细的临床评估，测定了锌和铜的水平，并分析了义齿霜的使用情况以及每日锌暴露量的估计。我们发现，在我们队列中 100% 的患者中，义齿霜是过量锌的来源。他们都有假牙不合适的历史，需要使用大量的假牙膏，导致大量的锌暴露。他们的铜和锌在停止使用假牙膏后恢复正常，进一步证实这是高锌的来源。不恰当地使用义齿霜似乎是这些患者体内锌过量的唯一来源。 (C) 2009 Elsevier Inc. 保留所有权利。
Neurodegeneration of the central and peripheral nervous system associated with hypocupremia and hyperzincinemia has been widely recognized but the origin of high zinc remained unknown. Denture cream has been recently suggested as one possible source of zinc, but the frequency with which denture fixative alone accounts for this syndrome is unknown. We analyzed the origin of excessive zinc in eleven patients with a progressive myelopolyneuropathy and unexplained hypocupremia with hyperzincinemia. These patients had a detailed clinical assessment, determination of zinc and copper levels, and analyzed use of denture cream with the estimates of daily zinc exposure. We identified denture cream as a source of excessive zinc in 100% patients in our cohort. They all had a history of ill-fitting dentures requiring large amounts of denture cream, resulting in significant zinc exposure. Their copper and zinc normalized after stopping denture cream, further confirming that this is the source of high zinc. Inappropriate use of denture cream appears to be the sole source of excessive zinc in these patients. (C) 2009 Elsevier Inc. All rights reserved.