GABA Detection with Nano-ITIES Pipet Electrode: A New Mechanism, Water/DCE-Octanoic Acid Interface.
GABA Detection with Nano-ITIES Pipet Electrode: A New Mechanism, Water/DCE-Octanoic Acid Interface.
复制标题
使用 Nano-ITIES 移液管电极检测 GABA：一种新机制，水/DCE-辛酸界面。
DOI：
10.1021/acs.analchem.7b03099
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发表时间：
2018-03-06
影响因子：
7.4
通讯作者：
Shen M
中科院分区：
文献类型：
--
作者：
Iwai NT;Kramaric M;Crabbe D;Wei Y;Chen R;Shen M
支承在吸管小孔上的两种不相容的电解质溶液之间的界面已成为检测各种分析物的强大平台。本文首次将纳米管电极用于γ-氨基丁酸的检测。在pH为≈7时，GABA在水溶液中的净电荷为零，以前在ITIES中没有检测到它。在这项工作中，我们展示了在pH≈7时检测水溶液中的γ-氨基丁酸，其中我们引入了一种新的检测策略，该策略基于“来自油相的pH调制”。据我们所知，这是第一份这样的报告。电流随着GABA浓度的增加而线性增加，范围从0.25 mM到1.0 mM。测得γ-氨基丁酸的半波转移电位为−0.401±0.010 V(n=22)vsE_1/2，tBA。测得γ-氨基丁酸在纳米管电极上的扩散系数为6.0 9(±0.5 8)×10−10m2/S(n=5)。实验结果表明，辛酸在油相中分解产生的质子不会从油相进入水相，也不会在水相中产生质子。本研究使用半径为320-340 nm的NanoITIES管状电极。这一新的策略和知识为未来CITS吸管电极的发展奠定了基础，特别是为检测电化学非氧化还原活性分析物奠定了基础。
Interface between two immiscible electrolyte solutions (ITIES) supported on the orifice of a pipet have become a powerful platform to detect a broad range of analytes. We present here the detection of γ-aminobutyric acid (GABA) with the nanoITIES pipet electrodes for the first time. GABA has a net charge of zero in an aqueous solution at pH ≈ 7, and it has not previously been detected at ITIES. In this work, we demonstrated GABA detection at ITIES in an aqueous solution at pH ≈ 7, where we introduced a novel detection strategy based on “pH modulation from the oil phase”. To the best of our knowledge, this is the first report of such. Current increases linearly with increasing concentrations of GABA, ranging from 0.25 mM to 1.0 mM. The measured half-wave transfer potential of GABA is −0.401 ± 0.010 V (n = 22) vs E1/2,TBA. The measured diffusion coefficient for GABA detection at nanoITIES pipet electrode is 6.09 (±0.58) × 10−10 m2/s (n = 5). Experimental results indicate that protons generated from octanoic acid dissociation in the oil phase do not come out from the oil phase into the aqueous phase; neither were protons produced in the aqueous phase. NanoITIES pipet electrodes with radii of 320–340 nm were used in the current study. This new strategy and knowledge presented here lays the groundwork for the future development of ITIES pipet electrodes, especially for the detection of electrochemically nonredox active analytes.
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影响因子：
7.4
作者：
Berduque, A;Sherburn, A;Arrigan, DWM
通讯作者：
Arrigan, DWM
DOI：
10.1016/0378-4347(93)80311-q
发表时间：
1993-05-05
期刊：
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS
影响因子：
--
作者：
GAMACHE, P;RYAN, E;ACWORTH, IN
通讯作者：
ACWORTH, IN
影响因子：
7.4
作者：
ALLISON, LA;MAYER, GS;SHOUP, RE
通讯作者：
SHOUP, RE
DOI：
10.1016/0160-5402(89)90029-6
发表时间：
1989-04-01
期刊：
JOURNAL OF PHARMACOLOGICAL METHODS
影响因子：
--
作者：
MURAI, S;NAGAHAMA, H;ITOH, T
通讯作者：
ITOH, T
影响因子：
4.9
作者：
Nestor, Uwitonze;Wen, Hanmei;Zhan, Dongping
通讯作者：
Zhan, Dongping