Rapid Quantification of Color Vision: The Cone Contrast Test
Rapid Quantification of Color Vision: The Cone Contrast Test
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DOI：
10.1167/iovs.10-6283
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发表时间：
2011-02-01
影响因子：
4.4
通讯作者：
Ivan, Douglas
中科院分区：
文献类型：
--
作者：
Rabin, Jeff;Gooch, John;Ivan, Douglas
目的。描述锥体对比测试 (CCT) 的设计、特异性和敏感性，这是一种基于计算机的锥体特异性（L、M、S）对比敏感度测试，用于诊断色觉缺陷 (CVD) 的类型和严重程度。方法。 CCT 呈现一系列随机的彩色字母，仅对 L、M 或 S 视锥细胞可见，并以递减的视锥细胞对比度逐步确定 L、M 和 S 字母识别阈值。通过回顾性比较 1446 名飞行员培训申请者的 CCT 评分与异常镜和伪等色板 (PIP) 结果来确定敏感性和特异性。 结果。 1446 名申请人中有 49 名 (3.4%) 检测出 CVD，1359 名男性中有 47 名 (3.5%) 检测出遗传性红绿（protan 或 deutan）CVD，1446 名男性中有 2 名检测到蓝黄色（tritan）CVD。与异常镜一致，CCT 显示 CVD 检测和分类的灵敏度为 100%（40 deutan、7 protan、 2 特里坦）。 PIP 测试显示出较低的敏感性（80% 检测到；20% 漏检），部分原因是申请人之前的经验和/或测试前准备。对于 L 和 M 视锥细胞测试，确认正常色觉的 CCT 特异性为 100%，对于 S 视锥细胞测试，CCT 特异性为 99.8%。结论。 CCT 的灵敏度和特异性与异常镜测试相当，并且超过了实践观察者的 PIP 灵敏度。 CCT 提供了一种快速（6 分钟）、临床上方便的色觉测量方法，用于量化正常颜色表现、诊断遗传性缺陷的类型和严重程度，以及检测由于眼部、神经系统和/或全身疾病以及损伤和生理压力源（例如海拔和疲劳）导致的获得性敏感性丧失。 （投资眼科可见科学。2011 年；52：816 - 820）DOI：10.1167/iovs.10-6283
PURPOSE. To describe the design, specificity, and sensitivity of the cone contrast test (CCT), a computer-based, cone-specific (L, M, S) contrast sensitivity test for diagnosing type and severity of color vision deficiency (CVD).METHODS. The CCT presents a randomized series of colored letters visible only to L, M or S cones in decreasing steps of cone contrast to determine L, M, and S letter-recognition thresholds. Sensitivity and specificity were determined by retrospective comparison of CCT scores to anomaloscope and pseudoisochromatic plate (PIP) results in 1446 applicants for pilot training.RESULTS. CVD was detected in 49 (3.4%) of 1446 applicants with hereditary red-green (protan or deutan) CVD detected in 47 (3.5%) of 1359 men and blue-yellow (tritan) in 2 of 1446. In agreement with the anomaloscope, the CCT showed 100% sensitivity for detection and categorization of CVD (40 deutan, 7 protan, 2 tritan). PIP testing showed lower sensitivity (80% detected; 20% missed) due in part to the applicant's prior experience and/or pretest preparation. CCT specificity for confirming normal color vision was 100% for L and M cone tests and 99.8% for S cones.CONCLUSIONS. The CCT has sensitivity and specificity comparable to anomaloscope testing and exceeds PIP sensitivity in practiced observers. The CCT provides a rapid (6 minutes), clinically expedient, measure of color vision for quantifying normal color performance, diagnosing type and severity of hereditary deficiency, and detection of acquired sensitivity loss due to ocular, neurologic, and/or systemic disease, as well as injury and physiological stressors, such as altitude and fatigue. (Invest Ophthalmol Vis Sci. 2011;52:816 - 820) DOI:10.1167/iovs.10-6283