Kinetics of recovery of CD4+ T cells in peripheral blood of deoxycoformycin-treated patients.
Kinetics of recovery of CD4+ T cells in peripheral blood of deoxycoformycin-treated patients.
复制标题
脱氧考福霉素治疗患者外周血中 CD4 T 细胞恢复的动力学。
DOI：
10.1093/jnci/83.22.1678
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Longo,DL
中科院分区：
文献类型：
--
作者：
Steis,RG;Urba,WJ;Kopp,WC;Alvord,WG;Smith2nd,JW;Longo,DL
目前毛细胞白血病患者的治疗选择包括脾切除术、干扰素α、2 '-脱氧共形霉素（DCF）和2-氯脱氧腺苷。治疗方案的选择应基于每种干预措施的疗效和长期毒性。虽然短疗程的DCF比干扰素治疗诱导更长持续时间的高应答率，但严重的细胞增殖抑制，
Current treatment options for patients with hairy-cell leukemia include splenectomy, interferon a, 2'-deoxycoformycin (DCF), and 2-chlorodeoxyadenosine. The selection of a treatment option should be based upon the efficacy and long-term toxicity of each intervention. Although shorter courses of DCF have been shown to induce high response rates of longer duration than interferon therapy, severe suppression of cellular