Multipoint gene mapping using seriation. I. General methods.

Multipoint gene mapping using seriation. I. General methods.
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发表时间:
1987-08
影响因子:
9.8
通讯作者:
Kenneth H. Buetow;Aravinda Chakravarti
Kenneth H. Buetow;Aravinda Chakravarti
中科院分区:
生物学1区
文献类型:
--
作者:
Kenneth H. Buetow;Aravinda Chakravarti

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初始和准确的推断位点的顺序和估计位点间的距离和干扰,可以使用序列化技术。该分析需要重组值的矩阵,其可以通过标准成对连锁分析来估计。这允许将来自个体研究者的结果结合起来,而不需要重新分析基本的系谱材料。序列化可以在不使用计算机的情况下进行。
Initial and accurate inference of locus order and estimates of interlocus distances and interference can be obtained using seriation techniques. The analysis requires a matrix of recombination values that can be estimated by standard pairwise linkage analysis. This allows combination of results from individual investigators without reanalysis of basic pedigree material. Seriation can be performed without the use of a computer.