Functional connectivity of negative emotional processing in adolescent depression.
Functional connectivity of negative emotional processing in adolescent depression.
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DOI：
10.1016/j.jad.2013.10.025
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发表时间：
2014-02
影响因子：
6.6
通讯作者：
Yang TT
中科院分区：
文献类型：
--
作者：
Ho TC;Yang G;Wu J;Cassey P;Brown SD;Hoang N;Chan M;Connolly CG;Henje-Blom E;Duncan LG;Chesney MA;Paulus MP;Max JE;Patel R;Simmons AN;Yang TT
亚膝前扣带回皮质(SgACC)及其连接的回路与青春期起病的严重抑郁障碍(MDD)的情绪功能密切相关。虽然最近的几项研究已经研究了静息抑郁青年的sgACC功能连接性(FC)，但到目前为止还没有研究探讨sgACC功能连接性在青少年抑郁症负性情绪处理过程中的作用。19名药物天真的MDD青少年和19名匹配的健康对照(HCL)在功能磁共振成像(FMRI)期间进行了内隐恐惧面部情绪识别任务。我们定义了双侧sgACC中的种子，并使用心理生理交互作用的方法评估了FC。在这项任务中，我们还使用认知行为模型来估计群体知觉敏感度的差异。最后，我们将连接强度与临床数据和知觉敏感度相关联。与HCL相比，抑郁青少年的sgACC-杏仁核Fc增加，sgACC-梭形回、sgACC-楔前、sgACC-岛和sgACC-额中回Fc降低(p<；0.05，校正)。在MDD中，sgACC-前楔形核Fc与抑郁严重程度呈负相关(p<；0.05，校正后)。最后，MDD青少年在任务中的知觉敏感度低于HCL，并且知觉敏感度的个体差异与sgACC FC和抑郁得分显著相关(p<；0.05，修正后)。受试者在临床上是同质的，这可能限制了研究结果的普遍性。青春期抑郁症与对负面刺激的偏向处理有关，这可能是由sgACC失调驱动的，并可能导致内在功能大脑网络之间的失衡。这项工作还建立了使用神经成像和认知行为建模相结合的方法来调查精神病患者和健康人群之间的认知和神经差异。
The subgenual anterior cingulate cortex (sgACC) and its connected circuitry have been heavily implicated in emotional functioning in adolescent-onset major depressive disorder (MDD). While several recent studies have examined sgACC functional connectivity (FC) in depressed youth at rest, no studies to date have investigated sgACC FC in adolescent depression during negative emotional processing. Nineteen medication-naïve adolescents with MDD and 19 matched healthy controls (HCL) performed an implicit fear facial affect recognition task during functional magnetic resonance imaging (fMRI). We defined seeds in bilateral sgACC and assessed FC using the psychophysiological interaction method. We also applied cognitive behavioral modeling to estimate group differences in perceptual sensitivity in this task. Finally, we correlated connectivity strength with clinical data and perceptual sensitivity. Depressed adolescents showed increased sgACC-amygdala FC and decreased sgACC-fusiform gyrus, sgACC-precuneus, sgACC-insula, and sgACC-middle frontal gyrus FC compared to HCL (p<0.05, corrected). Among the MDD, sgACC-precuneus FC negatively correlated with depression severity (p<0.05, corrected). Lastly, MDD adolescents exhibited poorer perceptual sensitivity in the task than HCL, and individual differences in perceptual sensitivity significantly correlated with sgACC FC and depression scores (p<0.05, corrected). Subjects were clinically homogenous, possibly limiting generalizability of the findings. Adolescent depression is associated with biased processing of negative stimuli that may be driven by sgACC dysregulation and may possibly lead to an imbalance among intrinsic functional brain networks. This work also establishes the use of combining neuroimaging and cognitive behavioral modeling methods to investigate cognitive and neural differences between psychiatric and healthy populations.