Role of polyunsaturated fatty acids in the management of Egyptian children with autism
Role of polyunsaturated fatty acids in the management of Egyptian children with autism
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DOI：
10.1016/j.clinbiochem.2008.05.013
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发表时间：
2008-09-01
影响因子：
2.8
通讯作者：
Khalil, Rehab O.
中科院分区：
文献类型：
--
作者：
Meguid, Nagwa A.;Atta, Hazem M.;Khalil, Rehab O.
目的：为了解孤独症儿童服用鱼油前后血中游离多不饱和脂肪酸（PUFAs）含量的变化及行为学评价，设计和方法：30名3-11岁孤独症儿童（男18名，女12名）和30名健康儿童（对照组）参加本研究。结果：服用Efalex（R）前，亚麻酸（71%）、二十二碳六烯酸（65%）和花生四烯酸（45%）明显减少，亚油酸（32%）减少最少。结论：补充多不饱和脂肪酸（PUFA）对改善孤独症儿童的行为有重要作用。(C)2008年加拿大临床化学家协会。爱思唯尔公司出版All rights reserved.
Objective: Estimation of free polyunsaturated fatty acids (PUFAs) in blood and evaluation of behavior of autistic children before and after taking fish oil (Efalex (R))) were performed.Design and methods: 30 autistic children (18 males and 12 females) aged 3-11 years and 30 healthy children as control group were included in this study. Tandem mass spectrometry and CARS were used to estimate the free PUFAs from dried blood spot and to evaluate the autistic behavior respectively.Results: Before taking Efalex (R), linolenic acid showed a significant reduction (71%), followed by docosahexaenoic acid (65%) and arachidonic acid (45%), while linoleic acid was the least affected PUFA (32%). After taking Efalex (R), 66% of autistic children showed clinical and biochemical improvement, linolenic acid and docosahexaenoic acid showed the highest levels after Efalex,11 supplementation.Conclusion: PUFA supplementation may play an important role in ameliorating the autistic behavior. (C) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.