Hypolipidemic Effect of Tomato Juice in Hamsters in High Cholesterol Diet-Induced Hyperlipidemia.
Hypolipidemic Effect of Tomato Juice in Hamsters in High Cholesterol Diet-Induced Hyperlipidemia.
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DOI：
10.3390/nu7125552
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发表时间：
2015-12-17
期刊：
影响因子：
5.9
通讯作者：
Huang CC
中科院分区：
文献类型：
--
作者：
Lee LC;Wei L;Huang WC;Hsu YJ;Chen YM;Huang CC
番茄是一种世界著名的食品，含有番茄红素、β-胡萝卜素、花青素和类黄酮等多种植物营养素。用于生产番茄汁、番茄酱、番茄酱和罐装番茄的升高的温度增强了生物活性组合物。我们旨在验证来自Kagome Ltd.的加工番茄汁（KOT）对由0.2%胆固醇和10%猪油饮食（即，高胆固醇饮食（HCD））。将雄性叙利亚金黄地鼠随机分为两组进行治疗：正常组（n = 8），标准饮食（对照）;和实验组（n = 32），HCD。将32只仓鼠进一步分为4组（每组n = 8），以2787、5573或13，934 mg/kg/天剂量经口灌胃给予溶剂或KOT，持续6周，分别指定为HCD-1X、-2X和-5X组。通过血清、肝脏和粪便的脂质谱以及临床生化和组织病理学来评价补充KOT的有效性和安全性。与对照组相比，HCD显著增加血清总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）水平，LDL-C/HDL-C比值，肝脏和胎儿TC和TG水平以及脂肪肝程度。KOT剂量依赖性地降低血清TC、TG、LDL-C水平、LDL-C/HDL-C比值、肝脏TC和TG水平以及粪便TG水平。我们的研究提供了基于实验的证据，以支持KOT可能是有用的治疗或预防高脂血症的发作。
Tomato is a globally famous food and contains several phytonutrients including lycopene, β-carotene, anthocyanin, and flavonoids. The increased temperature used to produce tomato juice, ketchup, tomato paste and canned tomato enhances the bioactive composition. We aimed to verify the beneficial effects of processed tomato juice from Kagome Ltd. (KOT) on hypolipidemic action in hamsters with hyperlipidemia induced by a 0.2% cholesterol and 10% lard diet (i.e., high-cholesterol diet (HCD)). Male Golden Syrian hamsters were randomly divided into two groups for treatment: normal (n = 8), standard diet (control); and experimental (n = 32), HCD. The 32 hamsters were further divided into four groups (n = 8 per group) to receive vehicle or KOT by oral gavage at 2787, 5573, or 13,934 mg/kg/day for six weeks, designated the HCD-1X, -2X and -5X groups, respectively. The efficacy and safety of KOT supplementation was evaluated by lipid profiles of serum, liver and feces and by clinical biochemistry and histopathology. HCD significantly increased serum levels of total cholesterol (TC), triacylglycerol (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), LDL-C/HDL-C ratio, hepatic and fetal TC and TG levels, and degree of fatty liver as compared with controls. KOT supplementation dose-dependently decreased serum TC, TG, LDL-C levels, LDL-C/HDL-C ratio, hepatic TC and TG levels, and fecal TG level. Our study provides experiment-based evidence to support that KOT may be useful in treating or preventing the onset of hyperlipidemia.