Au Nanocage Functionalized with Ultra-small Fe3O4 Nanoparticles for Targeting T1-T2Dual MRI and CT Imaging of Tumor.
Au Nanocage Functionalized with Ultra-small Fe3O4 Nanoparticles for Targeting T1-T2Dual MRI and CT Imaging of Tumor.
复制标题
DOI：
10.1038/srep28258
复制
发表时间：
2016-06-17
影响因子：
4.6
通讯作者：
Mei X
中科院分区：
文献类型：
--
作者：
Wang G;Gao W;Zhang X;Mei X
基于临床无创成像的多模式成像的诊断方法（例如。MRI/CT扫描仪）是近年来高度发展的，用于准确选择危重疾病的治疗方案。因此，开发适合MRI/CT多模态成像的多模态造影剂（MCAs）是非常必要的。本文通过组装Au纳米笼（Au NC）和超小氧化铁纳米颗粒（Fe 3 O 4），设计了一种新型的理想微阵列（F-AuNC@ Fe 3 O 4），用于同时进行T1-T2双MRI和CT对比成像。在该系统中，Au纳米笼提供了容易的硫醇修饰和用于CT成像的强X射线衰减特性。超小的Fe 3 O 4纳米颗粒作为优秀的造影剂，由于其超精细的尺寸，能够提供T1和T2加权MRI的极大增强信号（r1 = 6.263 mM−1 s−1，r2 = 28.117 mM−1 s−1）。功能化后，本发明的MCAs纳米粒子具有小的平均尺寸，低聚集和良好的生物相容性。体外和体内研究表明，MCA显示出长期循环时间、肾清除特性和在肿瘤组织中选择性蓄积的出色能力，用于同时CT成像和T1和T2加权MRI。总之，这些结果表明，所制备的MCA是MRI/CT多模态成像造影剂的优秀候选者。
Diagnostic approaches based on multimodal imaging of clinical noninvasive imaging (eg. MRI/CT scanner) are highly developed in recent years for accurate selection of the therapeutic regimens in critical diseases. Therefore, it is highly demanded in the development of appropriate all-in-one multimodal contrast agents (MCAs) for the MRI/CT multimodal imaging. Here a novel ideal MCAs (F-AuNC@Fe3O4) were engineered by assemble Au nanocages (Au NC) and ultra-small iron oxide nanoparticles (Fe3O4) for simultaneous T1–T2dual MRI and CT contrast imaging. In this system, the Au nanocages offer facile thiol modification and strong X-ray attenuation property for CT imaging. The ultra-small Fe3O4 nanoparticles, as excellent contrast agent, is able to provide great enhanced signal of T1- and T2-weighted MRI (r1 = 6.263 mM−1 s−1, r2 = 28.117 mM−1 s−1) due to their ultra-refined size. After functionalization, the present MCAs nanoparticles exhibited small average size, low aggregation and excellent biocompatible. In vitro and In vivo studies revealed that the MCAs show long-term circulation time, renal clearance properties and outstanding capability of selective accumulation in tumor tissues for simultaneous CT imaging and T1- and T2-weighted MRI. Taken together, these results show that as-prepared MCAs are excellent candidates as MRI/CT multimodal imaging contrast agents.