The Biological and Cellular Role of Fetuin Family Proteins in Biomineralization
The Biological and Cellular Role of Fetuin Family Proteins in Biomineralization
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胎球蛋白家族蛋白在生物矿化中的生物学和细胞作用
DOI：
10.1002/9783527619443.ch64
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Willi Jahnen-Dechent
中科院分区：
文献类型：
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作者：
Cora Schäfer;Willi Jahnen-Dechent
生物矿化的最后一步是在过饱和或亚稳盐溶液中自发发生的化学沉淀反应。在生理性骨形成（“骨生成”）以及病理性矿化（“异位矿化或钙化”）中，遗传程序引导前体细胞进入矿化能力状态。因此，所有不打算矿化的组织都必须积极保护，以防止矿物质的偶然沉淀。胎球蛋白-A是一种血液蛋白，作为异位矿化的有效抑制剂。胎球蛋白A缺陷小鼠出现严重的软组织钙化。胎球蛋白-A与钙和磷酸盐结合成称为钙蛋白颗粒的瞬时可溶性胶体颗粒。因此，胎球蛋白-A是一种病理性矿化的全身性抑制剂，补充了以细胞或组织限制性方式发挥作用的局部抑制剂。
The final step of biomineralization is a chemical precipitation reaction that occurs spontaneously in supersaturated or metastable salt solutions. In physiological bone formation, “osteogenesis”, and also in pathological mineralization, “ectopic mineralization or calcification”, genetic programs direct precursor cells into a mineralization‐competent state. Therefore, all tissues not meant to mineralize must be actively protected against the chance precipitation of mineral. Fetuin‐A is a blood protein that acts as a potent inhibitor of ectopic mineralization. Fetuin‐A‐deficient mice develop severe soft tissue calcification. Fetuin‐A combines with calcium and phosphate into transiently soluble colloidal particles termed calciprotein particles. Thus, fetuin‐A is a systemic inhibitor of pathological mineralization complementing local inhibitors acting in a cell‐ or tissue‐restricted fashion.