Peripheral unresponsiveness to human growth hormone in Laron dwarfism.
Peripheral unresponsiveness to human growth hormone in Laron dwarfism.
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拉伦侏儒症的外周对人类生长激素无反应。
DOI：
10.1056/nejm198011133032006
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Li,CH
中科院分区：
文献类型：
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作者：
Golde,DW;Bersch,N;Kaplan,SA;Rimoin,DL;Li,CH
1966年，Laron和他的同事描述了一种与高水平循环免疫反应的人类生长激素相关的严重形式的侏儒症。1 Laron侏儒症通常是一种家族性疾病，受影响的人通常对内源性或外源性生长激素的影响具有抵抗力。234567目前的证据表明，Laron侏儒症患者的循环生长激素在免疫化学和生化方面是正常的。在放射受体分析中发现患者体内的内源性生长激素正常结合。10因此推测，拉隆侏儒症是由于末端器官对生长无反应所致，但没有得到证实。
IN 1966 Laron and his associates described a severe form of dwarfism associated with high levels of circulating immunoreactive human growth hormone.1Laron dwarfism is usually a familial disorder, and affected persons are generally resistant to the effects of endogenous or exogenous growth hormone.234567Current evidence suggests that the circulating growth hormone in Laron dwarfs is immunochemically and biochemically normal.789Furthermore, Jacobs et al. have found that the endogenous growth hormone in affected persons binds normally in radioreceptor assays.10It has therefore been postulated, but not demonstrated, that the syndrome of Laron dwarfism is due to end-organ unresponsiveness to growth . . .